Toronto Blue Jays vs Tampa Bay Rays Picks and Predictions for Wednesday, September 17, 2025

By: David Anicetti Published 09/17/2025, 12:20 AM ET

The Toronto Blue Jays visit the Tampa Bay Rays on Wednesday at George M. Steinbrenner Field. The first pitch is scheduled for 7:05 PM ET on MLB.TV. Toronto enters 88–62 and sits 38–37 on the road. Tampa Bay is 73–77, and also 38–37 at home. The matchup is right-hander Kevin Gausman for Toronto against left-hander Ian Seymour for Tampa Bay. Toronto leads the American League East, while Tampa Bay trails the final AL wild card spot by 8.5 games. Knock it out of the park with expert MLB predictions.

Toronto Blue Jays Preview

Kevin Gausman has worked 177.2 innings this year with a 3.44 ERA and a 1.00 WHIP. He’s struck out 171 and walked just 45, limiting chances for opponents to string hits together. Toronto’s pitching as a whole has been respectable, holding a 4.13 ERA and 1.25 WHIP with opponents hitting .238.

At the plate, the Blue Jays have been one of the steadier lineups in the league. The Blue Jays are hitting .269/.337/.431 with 178 home runs and 751 runs scored. George Springer has been productive with 29 homers, 76 RBI, and a .302 average. Vladimir Guerrero Jr. adds a .301/.395/.490 line with 23 home runs, while Bo Bichette leads in average (.311) and RBI (94), though he is currently on the 10-day IL. Even without Bichette, Toronto has won five straight, including Monday’s 11-inning win over Tampa Bay.

Tampa Bay Rays Preview

Ian Seymour has been effective in his limited work, going 3–2 with a 3.16 ERA, 1.13 WHIP, and 52 strikeouts in 42.2 innings. The left-hander has allowed just three homers, showing he can keep the ball in the park. Tampa Bay’s staff has a 3.88 ERA, 1.21 WHIP, and opponents are batting .236. The pitching staff has been Tampa Bay’s strength all season.

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The Rays’ offense, however, has been streaky. As a team, the Rays are batting .251/.312/.403 with 171 home runs and 668 runs. Junior Caminero is the power source with 44 home runs and 108 RBI, while Yandy Díaz adds steady contact at .295 with a .356 on-base percentage. Jonathan Aranda has been a strong supporting bat at .316/.394/.478, but Tampa Bay has dropped four of its last five and scored only once in the loss to Toronto on Monday.

Toronto Blue Jays vs Tampa Bay Rays Prediction

Toronto holds the advantage in this matchup with Gausman’s consistency on the mound and a better batting order. Seymour has shown ability in limited innings, but the Blue Jays’ lineup is more complete, and the pitching staff has been steadier in recent weeks. Toronto is the safer bet. Final Score Prediction: Toronto Blue Jays win 4-2