Washington Nationals vs Cleveland Guardians Picks and Prediction for Wednesday May 27 2026

By: Eddie Kline Published 05/27/2026, 01:25 AM ET

Nationals Preview

In Wednesday afternoon MLB interleague action, the Washington Nationals will battle the Cleveland Guardians from Progressive Field. Be ready for the baseball season with all of our MLB predictions. The Nationals (29-27) are riding a four-game winning streak and have moved into second place in the NL East Division standings. Last night, leadoff hitter James Wood went 3-for-4 with a home run and scored twice to spark Washington to a 6-3 road victory against Cleveland.

Thirty-seven year old righty Miles Mikolas (1-3 6.17 ERA) will take the mound for the Nationals in this matchup. Last time out, Mikolas fired five shutout frames and did not walk a batter during a 5-4 road loss against Atlanta.

Guardians Preview

The Cleveland Guardians have won seven of their last ten games and hold a three-game cushion over Chicago for the top spot in the AL Central Division. During Tuesday’s home loss, Cleveland batters went 1-for-10 with runners in scoring position and left nine men on base. All-Star 3B Jose Ramirez drove in a pair of runs for the Guardians (32-25), who fell to 15-12 at home.

Twenty-six year old righty Gavin Williams (7-3 3.25 ERA) is making a strong case for his first All-Star Game appearance. Through 69 innings of work, Williams ranks fourth in the majors with 84 strikeouts and owns a solid 1.11 WHIP.

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Nationals vs Guardians Pick

Washington SP Jake Irvin has been placed on the 15-day injured list with a right shoulder strain. Through 56 games, Washington ranks 4th in OPS and 1st in runs scored. For the season, Cleveland ranks 19th in OPS and 16th in runs scored. Take the under. Final Score Prediction, Cleveland Guardians win 4-3.