Memphis Grizzlies vs Oklahoma City Thunder Picks and Prediction for Monday December 22 2025
Memphis vs Oklahoma City picks take center stage in this Western Conference matchup, and bettors scanning through NBA picks and NBA predictions are once again faced with a lopsided point spread involving a Thunder team that has dominated this series for years.
TLDR: Quick Picks and Prediction
- Spread Pick: Oklahoma City -16.5
- Total Pick: Under 229
- Projected Final Score: Oklahoma City 121, Memphis 102
Odds and Line Movement
Current Odds
| Team | Spread | Total |
|---|---|---|
| Memphis | +16.5 (-110) | Over 229 (-114) |
| Oklahoma City | -16.5 (-110) | Under 229 (-106) |
Line Movement - Spread
| Date | Time | Memphis | Oklahoma City |
|---|---|---|---|
| 12/21 | 07:32PM | +16.5 (-110) | -16.5 (-110) |
Line Movement - Total
| Date | Time | Over | Under |
|---|---|---|---|
| 12/22 | 07:24AM | 229 (-114) | 229 (-106) |
| 12/21 | 08:35PM | 228 (-112) | 228 (-108) |
| 12/21 | 07:58PM | 226 (-112) | 226 (-108) |
Key Matchups and Game Preview
Oklahoma City has completely owned this matchup, winning each of the last 14 meetings with Memphis. That dominance includes a 14-point road win in Memphis earlier this season and a playoff sweep last spring that firmly established the Thunder as a nightmare matchup for the Grizzlies.
Recent history also points strongly toward the under. Seven of the last eight meetings between these teams have stayed below the total, largely because Oklahoma City has been able to dictate pace and defensive intensity regardless of venue. The Thunder are coming off a loss in Minnesota on Friday, but they were in control for most of that game before a late rally by the Timberwolves. An extra day to rest and prep should help Oklahoma City reassert itself here.
Memphis, on the other hand, enters off a disappointing home loss to Washington as a double-digit favorite. That game was played without Ja Morant and Vince Williams Jr., and Brandon Clarke exited after just four minutes with a calf injury. Depth and shot creation remain major concerns for a Memphis team that has struggled mightily when asked to compete as a large underdog.
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Those struggles show up clearly in the numbers. When catching at least six points this season, Memphis is just 2-8 straight-up and 3-7 against the spread. This is not a profile that inspires confidence when stepping in front of a Thunder team that has been ruthless in these spots.
Both teams are on the front end of a back-to-back, but Oklahoma City’s situation is far more favorable. The Thunder travel to San Antonio next, while Memphis has to head to Utah, a trip that often forces teams to manage minutes and pace more conservatively.
Betting Trends for MEM and OKC
- Oklahoma City has won 14 straight meetings against Memphis.
- Seven of the last eight meetings have gone under the total.
- Memphis is 3-7 against the spread as an underdog of six points or more this season.
- Oklahoma City is 11-6 against the spread as a double-digit favorite.
Key Injuries and Things To Know for MEM and OKC
- MEM: Ja Morant did not play in the last game.
- MEM: Vince Williams Jr. did not play in the last game.
- MEM: Brandon Clarke left the last game early with a calf injury.
Side and Over and Under Picks
- Side: Oklahoma City -16.5
- Total: Under 229
Final Score Prediction
Oklahoma City 121, Memphis 102
How to Wager On Memphis vs Oklahoma City
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