Philadelphia 76ers vs Boston Celtics Picks and Prediction for Wednesday October 22 2025
76ers Preview
In Wednesday night NBA action, the Philadelphia 76ers will travel to TD Garden to face the Boston Celtics. For other NBA action see our NBA Predictions. The 76ers (24-58) are looking to rebound from an injury ravaged season and are looking to advance to the Eastern Conference Finals for the first time since 2001. Philadelphia head coach Nick Nurse is confident that G Tyrese Maxey (26.3 ppg) is ready to become a bonafide number one option on offense.
Seven-time All-Star Joel Embiid played in just 19 games last year and if he can double that then the 76ers could be dangerous in a watered down Eastern Conference. Number three overall draft pick V.J. Edgecombe has been opening eyes with his athleticism and will be exciting to watch from day one.
Celtics Preview
The Boston Celtics captured their 18th NBA Championship in 2024 and have reached the playoffs in 11 consecutive years. The Celtics (61-21) will be hard pressed to duplicate their recent playoff success after losing All-Star F Jayson Tatum to a torn righty Achilles tendon. Boston moved on from veterans Jrue Holiday, Kristaps Porzingis and Al Horford in the offseason.
All-Star G Jaylen Brown will be the focal point of the Boston offensive attack and G Payton Pritchard will take on an increased scoring role. Derrick White provides plenty of versatility and newly acquired G Anferenee Simons could flourish for the Celtics.
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76ers vs Celtics Pick
Philadelphia G Paul George (knee) and G Jared McCain (thumb) will not play in this game. Boston G Jaylen Brown is dealing with a hamstring issue and is listed as questionable for this contest. Much has been made about the Celtics’ gap year, but this team has too much pride to be counted out at home. Take Boston to win and cover. Final Score Prediction, Boston Celtics win 118-109.
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