Philadelphia 76ers vs Cleveland Cavaliers Picks and Prediction for Wednesday November 5 2025

By: Eddie Kline Published 11/05/2025, 12:40 AM ET

76ers Preview

The Wednesday NBA schedule will get underway with a matchup between the Philadelphia 76ers and the Cleveland Cavaliers from Rocket Arena. For other NBA action see our NBA Predictions. The 76ers (5-2) are looking to rebound from an injury ravaged season and rank third in the league in offensive efficiency. Last night, Philadelphia was unable to protect a 24-point lead during a 113-111 road loss against Chicago.

Philadelphia G Tyrese Maxey erupted for a game-high 39 points on 14-for-26 shooting and dished out five assists. Joel Embiid added 20 points (7-21 FG) and six rebounds for the 76ers, who were outrebounded by a 48-40 margin.

Cavaliers Preview

The Cleveland Cavaliers have won two of their first three home games and have been eliminated from the Eastern Conference Semifinals in consecutive years. The Cavaliers (4-3) rank seventh in the league in defensive efficiency and are allowing a shade below 114 points per contest. On Sunday, Cleveland forced 23 turnovers during a 117-109 home victory versus Atlanta.

All-Star G Donovan Mitchell nailed 8-for-15 from the three-point line and finished with a game-high 37 points. Atlanta F De’Andre Hunter chipped in 19 points (5-14 FG) and seven rebounds. All-Star F Evan Mobley added 14 points, eight rebounds, and five assists for the Cavaliers.

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76ers vs Cavaliers Pick

Cleveland starters Jarrett Allen (finger) and Darius Garland (toe) are listed as questionable for this contest. These two teams rank in the top ten of the league in tempo and the 76ers are playing on consecutive nights. Look for the Cavaliers to win at home in a game that goes over the total. Final Score Prediction, Cleveland Cavaliers win 127-119.