San Antonio Spurs at Los Angeles Lakers Picks and Predictions for Wednesday, November 5, 2025

By: David Anicetti Published 11/05/2025, 12:20 AM ET

The San Antonio Spurs visit the Los Angeles Lakers on Wednesday night at crypto.com Arena. San Antonio is 5–1 overall and 2–1 away, after a 130–118 loss at Phoenix. Los Angeles is 6–2 overall and 2–2 at home, after a 123–115 win at Portland. Build your bankroll using our free NBA picks.

Game Information for Spurs vs Lakers

Date & Time: Wednesday, November 5, 10:00 PM ET

Where: crypto.com Arena, Los Angeles, California

TV: ESPN

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San Antonio Spurs Preview

San Antonio is averaging 118.2 points per game while shooting 49.8% from the field. Victor Wembanyama leads the Spurs with averages of 26.7 points, 13.7 rebounds, and 4.7 blocks. Stephon Castle adds 20.0 points and 5.3 assists per game, giving the Spurs balanced play on both ends. Devin Vassell contributes 14.7 points, and Keldon Johnson scores 13.0 per game on 61% shooting. San Antonio averages 47.8 rebounds and 11.7 made threes at 35.2%.

The Spurs are sharing the ball well with 24 assists per game and continue to get steady production from their starters. When they stay within their set offense and take care of the ball, they create effective inside-out looks for Wembanyama and outside shooters. Jeremy Sochan, Luke Kornet, Lindy Waters III, and Kelly Olynyk are listed as game-time decisions, while Dylan Harper remains out.

Los Angeles Lakers Preview

Los Angeles is averaging 119.3 points while shooting 52.0% from the floor and recording 27 assists per game. Luka Doncic leads the Lakers, averaging 41.3 points and 11.3 rebounds per game. Austin Reaves is the leader in assists at 9.3 per game. Deandre Ayton adds 14.8 points and 7.8 rebounds, and Rui Hachimura chips in with 15.3 points.

The Lakers average 41 rebounds and 10 made threes per game while shooting 32.5% from deep. The Lakers have several players, including Doncic and Reaves, listed as questionable for Wednesday’s matchup with the Spurs. The Lakers have won four straight, scoring at least 115 points in each game.

San Antonio Spurs at Los Angeles Lakers Prediction

Both teams have started strong offensively, but San Antonio’s frontcourt and rebounding give them an advantage in a close matchup, especially if Doncic and Reaves do not play. Wembanyama’s scoring and Castle’s guard play will help the Spurs win in the final seconds. Final Score Prediction: San Antonio Spurs win and cover ATS 115-114.