College Basketball Parlay Picks for Tuesday, December 16, 2025
The college basketball season has plenty of high caliber games on tap on Tuesday. These games have made it very easy for us to find a great 2 leg college basketball parlay for Tuesday 12/16/25.
Check out our parlays, as well as all of our college basketball picks.
College Basketball Parlay
- Toledo vs Michigan State – Michigan State -23.5 (-102)
- South Carolina vs Clemson – Clemson Team Total Over 76.5 Points
Leg 1 – Toledo Rockets vs Michigan State Spartans
This matchup is extremely lopsided on paper and statistically. Michigan State owns a 97.4% matchup win probability according to ESPN Analytics and allows just 62.1 points per game, one of the best defensive marks in the country.
Toledo plays at a fast pace and scores 82.6 PPG, but that number is inflated by weaker competition. Against higher-level defensive teams, the Rockets have struggled to control tempo and protect the ball. Michigan State’s rebounding edge (41.6 RPG vs 35.6) and interior defense should limit second-chance opportunities and lead to extended scoring runs.
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At the Breslin Center, Michigan State has consistently buried overmatched opponents, and this is a classic spot where Tom Izzo’s team builds a double-digit halftime lead and continues to apply pressure in the second half. Check out the Michigan State vs Toledo pick.
Pick: Michigan State -23.5
Leg 2 – South Carolina Gamecocks vs Clemson Tigers (Team Total)
Rather than laying double digits in a rivalry game, the better angle here is Clemson’s team total. The Tigers are averaging 81.8 points per game and are facing a South Carolina defense that has not been tested by many high-efficiency half-court offenses.
Clemson is 6–0 at home and plays at a controlled but efficient pace, shooting well inside the arc and dominating the glass (41.4 RPG). South Carolina allows 68.2 PPG, but those numbers come largely against mid- and low-major opponents.
In a rivalry setting at Littlejohn Coliseum, Clemson should push the tempo selectively and capitalize at the free-throw line late, making the team total a safer and more predictable angle than the full-game spread. Check out the South Carolina vs Clemson pick.
Pick: Clemson Team Total Over 76.5 Points
Final Thoughts
This parlay blends a high-confidence spread with a controlled offensive angle, reducing volatility while maintaining strong payout value:
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Michigan State’s defensive dominance at home
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Clemson’s consistent scoring output in a favorable matchup
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