Creighton vs Depaul Pick & Prediction for Wednesday, February 12, 2026

By: Ricky Mackenzie Published 02/11/2026, 12:55 AM ET

Creighton Preview

Creighton comes into this matchup trying to build consistency after a narrow 69-68 win over Seton Hall in its most recent game. Get our free College Basketball Picks all season long! That contest was slow and physical, with Creighton leaning heavily on half-court execution and late defensive stops to escape. Shooting was uneven, but ball security and rebounding kept them in control during key stretches.

DePaul Preview

DePaul enters after a disappointing 90-72 loss to Providence, a game that exposed ongoing defensive issues. Providence dictated tempo early, found clean perimeter looks, and consistently won second-chance opportunities. DePaul struggled to recover once momentum shifted and was forced to chase the game for most of the night. That loss marked their fourth straight defeat and continued a troubling trend of defensive breakdowns against structured conference opponents.

Creighton vs DePaul Prediction

The matchup favors Creighton’s ability to slow games down and force execution. The Bluejays are comfortable grinding possessions, using spacing and patience to create shots late in the clock. DePaul prefers to speed things up, but when transition chances are limited, offensive efficiency drops significantly.

Home court gives DePaul some hope, but recent performances suggest discipline will matter more than energy. Creighton has been more reliable in close situations, particularly when games tighten late.

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Creighton’s recent defensive improvement and comfort in close games give them the edge in this spot. DePaul’s ongoing struggles on that end make it difficult to trust them against a patient opponent. If Creighton controls tempo and limits mistakes, the advantage should show late. Final Score Prediction, Creighton Bluejays win 74-69.

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