DePaul vs Creighton Pick & Prediction for Wednesday, February 25, 2026

By: Ricky Mackenzie Published 02/25/2026, 02:05 AM ET

DePaul Preview

DePaul enters this matchup at 14-13 after a narrow 71-68 loss to Providence, a game that slipped away late due to execution issues in the half court. Get our free College Basketball Picks all season long! The Blue Demons have been competitive in recent outings but continue to struggle finishing possessions defensively. At home, they’ve shown more offensive rhythm, particularly when attacking downhill and drawing fouls.

Creighton Preview

Creighton sits at 14-14 and comes in motivated after an 81-52 loss to St. John’s exposed major offensive inconsistencies. The Bluejays rely heavily on perimeter shooting and structured half-court sets, but when early shots don’t fall, scoring droughts follow. Defensively, however, Creighton remains disciplined, contesting shooters and limiting easy transition points.

DePaul vs Creighton Prediction

The key matchup revolves around pace. DePaul is most effective when pushing tempo and turning defense into quick offense, while Creighton prefers a controlled, methodical approach. If the Bluejays slow the game down and force DePaul into contested jumpers late in the shot clock, they’ll gain a significant advantage. Conversely, turnovers leading to fast-break opportunities could quickly swing momentum toward the home side.

Betting markets list Creighton as a moderate favorite, reflecting their defensive structure and recent consistency against mid-tier conference opponents. DePaul’s home floor provides an emotional edge, but execution in the final five minutes will likely determine the outcome.

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Expect a competitive conference battle with stretches of scoring droughts on both sides. Creighton’s defensive discipline and ability to dictate tempo should allow them to control key possessions late, even on the road. DePaul will keep it close behind home energy, but shot selection could prove costly. Final Score Prediction, Creighton Bluejays win 71-64.

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