DePaul vs Villanova Picks and Predictions for Wednesday, December 31, 2025

By: Cameron Ross Published 12/31/2025, 03:10 AM ET

DePaul vs Villanova Information

The DePaul Blue Demons will be on the road Wednesday, playing the Villanova Wildcats in Pennsylvania at 6:00 PM. DePaul has eight wins and five losses this season, riding a two-game skid into Wednesday after an 18-point home loss to Connecticut in their last outing. The Villanova Wildcats have ten wins and two losses this season after winning four of the previous five, including three in a row, following an 8-point road victory against Seton Hall. Stay in the news with our College Basketball Picks.

DePaul Preview

The DePaul offense has been solid this year, averaging 74.7 points on 45% shooting from the floor this season. Defensively, the Blue Demons are allowing 69 points per game overall, and they've given up an average of 75.5 points per game during their two-game losing streak. CJ Gunn leads the DePaul offense this season, averaging 13.8 points per game. Layden blocker averages 10.9 points to go along with the team-leading 3.8 assists. NJ Benson also averages 10.9 points per game and leads DePaul, pulling in 6.6 rebounds per contest.

Villanova Preview

Offensively, Villanova has been stout this season, allowing 78.7 points on 47% shooting from the floor. Defensively, the Wildcats have been elite, holding opponents under 67 points per game this season, and gave up only 56 points in their most recent win. Bryce Lindsay leads the Villanova offense, averaging 16.6 points per game. Acaden Lewis is second on the roster, averaging 12.3 points to go along with the team's leading 5 assists per game. Duke Brennan averages 12 points and leads the way, averaging 11.4 rebounds.

DePaul vs Villanova Prediction

Villanova is a far better team in this matchup, and it will show from early on Wednesday. Look for the Wildcats to dominate this game in every aspect as they roll past DePaul. Take Villanova to continue to roll as they get an easy win and cover Wednesday night at home. Final Score Prediction, Villanova Wildcats win and cover 87-63. Betting on sports and on DePaul is easy, but even easier if you use the best sportsbooks. Make sure you know about how the fans are looking on prediction markets for Villanova with the Novig promo code. Make sure when you place your bet on Villanova vs DePaul you are using the BetMGM bonus code.

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