Louisville vs. Indiana Picks and Prediction for Saturday, December 6, 2025
On Saturday, the Louisville Cardinals (7-1) face off against the Indiana Hoosiers (7-1) at Gainbridge Fieldhouse in Indianapolis, Indiana. This game will air on CBS. Keep up to date with all the NCAAB action, with our College Basketball predictions.
Louisville vs. Indiana Game Information
- December 6, 2025
- 5:00pm EST
- Burns Arena
- ESPN+
Indiana Form & Recent Results
Indiana enters this game hoping to bounce back after a loss in their previous game, but overall, they've been playing well lately, coming out on top in four of their last five matchups. In their recent 73-64 defeat against Minnesota, Tayton Conerway stood out for the Hoosiers, putting up 18 points. Throughout the season, Indiana has relied on Tucker DeVries to lead the way in scoring, he’s averaging 16.8 points per game. Right behind him is Lamar Wilkerson, who’s been a consistent contributor with 16.5 points each game so far this year. On the boards, Sam Alexis has been their top rebounder, pulling down an average of six rebounds per game. Tayton Conerway isn’t just a scorer; he also sets up his teammates, leading Indiana with 4.9 assists per game. Over their last five games, the Hoosiers have averaged 78.4 points, and they’ll be aiming to keep their offense clicking as they try to pull off an upset against the sixth-ranked Louisville Cardinals in Indianapolis.
Louisville Form & Recent Results
Louisville comes into this game hoping to bounce back after a tough loss, but overall, they've been playing pretty well lately, taking three wins out of their last five games. In their recent 89-80 defeat to Arkansas during the ACC/SEC Men’s Challenge, Mikel Brown Jr. put in a strong performance, leading the team with 22 points. Looking at the season so far, Ryan Conwell has been the Cardinals' top scorer, putting up an impressive 19.5 points per game. Close behind him is Mikel Brown Jr., who’s averaging 17.6 points this year. On the boards, Sananda Fru has made the biggest impact, averaging 6.1 rebounds, while Mikel Brown Jr. also stands out for his playmaking with a team-high 5.6 assists per game. Recently, Louisville’s offense has been on fire. They’ve averaged 90.2 points per game over their last five matchups. Now, they'll look to keep that high-scoring trend going as they aim to get back on track and take down the Hoosiers in this important game.
Key Players
- Louisville’s Mikel Brown Jr. this season: 17.6 points, 5.6 assists this season
- Indiana’s Tayton Conerway this season: 4.9 assists this season
Betting Odds & Market Overview:
- LOU -4.5; O/U 159.5
Louisville vs. Indiana Picks and Prediction
Louisville and Indiana are set to face off in Indianapolis, each entering the game with an impressive record. Both teams have secured victories in seven out of their first eight matchups this season. Louisville, currently ranked sixth in the nation, will be hoping to maintain their momentum and avoid a stumble against an Indiana squad sitting at number twenty-two. With both teams showcasing flashes of brilliance on offense so far, they'll look to out-duel each other in this exciting upcoming matchup. Final Score Prediction, Louisville Cardinals win but fail to cover the spread, 79-76. The best sportsbooks are the best way to go when you are betting on Louisville. Make sure you know about how the fans are looking on prediction markets for Indiana with the Onyx Odds promo code. Getting the most out of your bets on Louisville vs Indiana can be done by using the Fanatics Sportsbook promo code.
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