Oklahoma State Cowboys vs Colorado Buffaloes Picks and Prediction for Saturday February 21 2026

By: Dylan Hellebrand Published 02/21/2026, 12:55 AM ET

On Saturday, the Oklahoma State Cowboys (16-10) face off against the Colorado Buffaloes (14-12) at the CU Events Center in Boulder, Colorado. This game will air on TNT and truTV. Keep up to date with all the NCAAB action, with our College Basketball predictions.

Oklahoma State vs. Colorado Game Information

February 21, 2026
3:30pm EST
CU Events Center
TNT/truTV

Colorado Form & Recent Results

Colorado heads into this matchup trying to stop a bit of a slide, as they’ve lost two straight games and have dropped three of their last five overall. Their most recent game was a tough one to swallow, as it ended in a 90–86 overtime loss on the road against No. 22 BYU in Provo on Saturday. Even in the loss, Isaiah Johnson was a major bright spot, pouring in 27 points and keeping the Buffaloes within striking distance throughout the extra period.

This season, Johnson has been Colorado’s most reliable scoring option, leading the team at 16.5 points per game. Barrington Hargress has also been a consistent contributor, sitting second on the team with 14.1 points a night, and he’s been the primary playmaker as well, leading the Buffaloes with 4.3 assists per game. On the glass, Bangot Dak has been Colorado’s top rebounder this season, averaging 6.5 boards. Defensively, Colorado has had some issues lately, giving up about 77 points per game over their last five games, and their conference record reflects that struggle, as they’ve lost nine of their fourteen conference games this season. Now, back at home, they’ll be looking for a turnaround and a chance to snap the two-game losing streak with a win over the Oklahoma State Cowboys.

Oklahoma State Form & Recent Results

Oklahoma State comes into this game in a rough patch lately, currently riding a four-game losing streak and having lost four of its last five games overall. The Cowboys are coming off an 81–69 home loss to No. 8 Kansas on Wednesday, a game where Parsa Fallah was the bright spot offensively as he poured in 21 points to keep Oklahoma State within striking distance. Still, the results lately haven’t gone their way, and they’ll be looking to turn the season around by putting together a more complete performance away from home.

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Anthony Roy has been the Cowboys’ most reliable scoring option overall this year, leading the team at 17.5 points per game. Fallah has been a strong secondary threat as well, ranking second on the roster at 14.5 points per game, and he also sets the tone on the glass by leading Oklahoma State with 6.1 rebounds a night. When it comes to creating shots for others, Kanye Clary has been the main playmaker, averaging 5 assists per game this season. The biggest concern, though, has been the defensive end: over their last five games, the Cowboys have given up an average of 87.4 points, a sign that stops have been hard to come by. If they want to change the direction of their season, they’ll need to tighten things up defensively and find answers on the road against Colorado.

Key Players

Oklahoma State’s Parsa Fallah this season: 14.5 points, 6.1 rebounds per game
Colorado’s Barrington Hargress this season: 14.1 points, 4.3 assists per game

Betting Odds & Market Overview:

COLO -3.5; O/U 163.5

Oklahoma State vs. Colorado Picks and Prediction

Oklahoma State’s defense hasn’t been at its best over the last few games, and the Cowboys will be looking to tighten things up and change the direction of their season when they head to Colorado for this road game. Both teams have struggled in conference play with Colorado and Oklahoma State having each lost nine of their thirteen conference games, so this matchup feels like a real chance for one of them to pull even, build some momentum, and gain an edge over the other in the standings. Final Score Prediction, Colorado Buffaloes win and cover the spread, 89-76.

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