Oklahoma State Cowboys vs Iowa State Cyclones Picks and Prediction for Saturday, January 10, 2026

By: Jake Allman Published 01/10/2026, 02:00 AM ET

Oklahoma State heads to Ames to face unbeaten Iowa State on Saturday, January 10, with the tipoff at 4:00 PM ET on ESPN2. The Cowboys enter at 13-2 overall and 1-1 in Big 12 play, while the Cyclones sit at a perfect 15-0 and 2-0 in conference action. ESPN Analytics heavily favors Iowa State, giving the Cyclones a 94.8 percent chance to win, and Hilton Coliseum has been a tough venue for visiting teams. Oklahoma State has shown offensive firepower recently, but this matchup represents a clear step up in competition. Slam dunk your bets with our College Basketball picks.

Oklahoma State Preview

Oklahoma State averages 90.2 points per game while allowing 79.7, a game plan built around perimeter shooting. Anthony Roy leads the Cowboys at 17.5 points per game while shooting 47.8 percent from the field and an elite 46.9 percent from three. Vyctorius Miller adds 14.9 points per game and gives Oklahoma State another reliable scorer, but ball security has been inconsistent with 13.1 turnovers per contest. Recent results include a dominant 103-77 win over BCU, but a 102-80 road loss at Texas Tech showed how vulnerable Oklahoma State can be away from home.

Iowa State Preview

Iowa State has been one of the most balanced teams in the country, scoring 88.3 points per game while giving up only 62.4. Joshua Jefferson leads the Cyclones with 17.6 points, 7.9 rebounds, and 5.2 assists per game, anchoring nearly every phase of the offense. Milan Momcilovic adds 17.5 points per game while shooting 54.7 percent from three, stretching defenses and creating spacing. Iowa State also forces mistakes at a high rate, averaging 9.7 steals per game, which feeds into a fast and efficient scoring attack.

Oklahoma State vs Iowa State Prediction

The matchup strongly favors Iowa State’s ability to control tempo and limit second chances. The Cyclones shoot 52 percent from the field as a team and hold opponents well below Oklahoma State’s usual scoring range. Oklahoma State’s rebounding edge is modest, and facing Iowa State’s disciplined half-court execution on the road is a difficult task. If Iowa State continues to limit turnovers and defend the perimeter, the Cyclones should dictate the flow from the opening tip.

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The pick is Iowa State minus the points at home, as the Cyclones have consistently separated from opponents with defense and effective shooting. A projected final score of Iowa State 82, Oklahoma State 68 fits both teams’ profiles. The under is also worth consideration, given Iowa State’s 62.4 points allowed per game and the likelihood that Oklahoma State struggles to reach its season average in this environment.

How To Bet This Matchup

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