San Francisco vs Colorado Picks and Prediction for Thursday, November 27, 2025

By: Jake Allman Published 11/27/2025, 12:35 AM ET

San Francisco and Colorado meet in Palm Springs for a neutral-site matchup between two strong teams. The Dons are 5-1 with four straight wins, while Colorado brings a 5-0 record and one of the most productive offenses in the country. Tip-off is 2:00 PM ET at Acrisure Arena on CBSSN, with both teams entering in rhythm. March isn’t the only madness — today’s college basketball picks are ready to cash.

San Francisco Preview

San Francisco averages 80.7 points per game and allows only 65.3. The Dons shoot 48 percent from the field and rely on steady guard play. Ryan Beasley leads at 16.0 points per game on 51.9 percent shooting and hits 40.7 percent from deep. Mookie Cook adds 13.3 points while converting 63.3 percent from the floor and 59.1 percent from three. Tyrone Riley IV contributes 11.2 points, and David Fuchs provides the inside presence with 6.5 rebounds per game.

San Francisco’s recent form includes wins over Minnesota, Northwestern State, Bradley, and Portland State. Each victory carried a comfortable margin, helped by 39.7 rebounds per game and 7.5 steals. The Dons turn it over 13.7 times per game, which is manageable for a team that prefers pace. The challenge here comes from facing a Colorado lineup that scores at a much higher clip than recent opponents. The best sportsbooks are the best way to go when you are betting on San Francisco.

Colorado Preview

Colorado averages 94.4 points per game and shoots 53 percent while spreading the floor with multiple scorers. Sebastian Rancik posts 14.8 points per game and shoots 93.9 percent from the line. Isaiah Johnson matches his scoring at 14.8 on 57.6 percent shooting and 58.8 percent from three. Alon Michaeli adds 12.8 ppg, and Barrington Hargress generates 5.6 assists per game. Bangot Dak adds 12.0 ppg, 7.2 rebounds, and 1.4 blocks.

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Colorado’s last five games include four outings with at least 94 points and a 102-point showing in overtime. The Buffaloes shoot 42.2 percent from deep and average 37 rebounds with 6.6 steals. The ability to create quick scoring bursts and consistently generate open looks gives them a strong advantage on a neutral floor. Make sure you know about how the fans are looking on prediction markets for Colorado with the Onyx Odds promo code.

Colorado vs San Francisco Prediction and Reasoning

Colorado has superior scoring and more shooting threats, while San Francisco’s rebounding and ball movement should keep the game close. The Buffaloes’ high shooting percentages and depth off the bench will help create an advantage on the scoreboard late. Getting the most out of your bets on San Francisco vs Colorado can be done by using the Fanatics Sportsbook promo code.

Final Score Prediction: Colorado 86, San Francisco 79

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