Siena Saints vs Duke Blue Devils Picks and Predictions for Thursday March 19 2026

By: Kim Smith Published 03/19/2026, 12:35 AM ET

The Siena Saints take on the Duke Blue Devils at Bon Secours Wellness Arena in Greenville, South Carolina, with tip-off set for 2:50 PM on CBS. Duke enters as a massive -20000 favorite while Siena is +3500, with the total set at 135.5 and the Blue Devils favored by 27.5 points. Be sure to check out our free college basketball picks for more tournament plays and daily insights.

Saints Look to Stay Competitive Against Powerhouse

Siena comes into this matchup with a 23-11 record and solid recent form, recently winning over Merrimack, Fairfield, Mount St. Mary’s, and Rider while recently losing to Fairfield. They have shown the ability to win consistently at their level.

The Saints average 70.5 points per game while allowing 65.7, shooting 46% from the field. They also contribute 34.4 rebounds and 13.4 assists per game, focusing on efficiency and half-court execution.

One of Siena’s strengths is their disciplined defensive approach, as they limit scoring opportunities and keep games at a slower pace. However, they will be tested against a high-level opponent in this matchup.

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Blue Devils Dominating on Both Ends

Duke enters this game with an elite 32-2 record and has been dominant recently, recently winning over Virginia, Clemson, Florida State, North Carolina, and NC State. Their consistency against top competition has been impressive.

The Blue Devils average 82.3 points per game while allowing just 63.1, shooting an efficient 49% from the field. They also dominate the glass with 40.3 rebounds and add 16.9 assists per game.

Duke’s biggest strength is their ability to control games on both ends of the floor. Their defensive efficiency combined with offensive balance makes them one of the toughest teams to beat.

Siena vs Duke Pick

Duke -27.5

Duke has a clear advantage in talent, depth, and overall efficiency. While Siena is a solid team, the Blue Devils’ ability to dominate defensively and score efficiently should allow them to win comfortably and cover the large spread.

Siena vs Duke Total Pick

Under 135.5

I’m leaning toward the under here because Duke’s defense can limit scoring opportunities, and Siena plays at a slower pace. This combination should keep the total from getting too high.

Final Score Prediction: Duke 78, Siena 52

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