Syracuse vs Iowa State Picks and Predictions for Wednesday, November 26, 2025

By: Cameron Ross Published 11/26/2025, 11:21 AM ET

Syracuse vs Iowa State Information

The Syracuse Orange remain in Las Vegas on Wednesday afternoon, where they face the Iowa State Cyclones in the Players Era Festival. Syracuse has four wins and two losses this season, coming into this matchup riding a 2-game skid after an 11-point loss to Kansas in their last outing. Iowa State is the #15-ranked team in the nation, undefeated through six games played, following an 18-point win over Creighton on Tuesday. Stay in the news with our College Basketball Picks.

Syracuse Preview

The Syracuse offense has been strong this season, averaging 80 points on 51% shooting from the floor, but the Orange has averaged only 67 points per game in their two losses. Defensively, Syracuse is allowing 60.3 points per game this season, but has given up an average of 74.5 points per game during its two-game losing streak. Donnie Freeman leads the Syracuse offense this season, averaging 17.8 points per game. Kiyan Anthony is second on the roster, averaging 13.8 points in 26 minutes per contest. Big man William Kyle III averages 10.2 points to go along with the team-leading 9 rebounds per game. Naithan George is averaging 11.4 points and leads the team, dishing out 5.8 assists.

Iowa State Preview

The Iowa State Cyclones offense has been the team's biggest strength this season, averaging 93 points on 52% shooting from the floor. Defensively, Iowa State has been even better, holding opponents to 65.2 points per game through six games played, and gave only 60 points in their victory against Creighton. Joshua Jefferson leads the Iowa State offense this season, averaging 18.4 points and 7.8 rebounds per game. Tamin Lipsey is also averaging 18.4 points to go along with the team-leading 5.2 assists per game. Milan Momcilovic is third on the roster, averaging 16.8 points as the only other player on the team in double digits.

Syracuse vs Iowa State Prediction

Both teams are playing good basketball coming into this matchup, but Iowa State is the better team. Look for the Cyclones to dominate the game on both sides of the ball. They were overwhelmed by A struggling Syracuse team. Take Iowa State on Wednesday afternoon to remain undefeated as they get the win and cover in Las Vegas. Final Score Prediction, Iowa State Cyclones win and cover 79-65.

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