Villanova vs DePaul Picks and Predictions For Wednesday March 4 2026

Villanova Preview

The Villanova Wildcats are heading to Wintrust Arena on Wednesday, where they will take on the DePaul Blue Demons. Get the rest of our free college basketball picks here! The Villanova Wildcats enter this Big East Conference matchup with a 22-7 overall record and a 13-5 mark in league play, giving them one of the stronger résumés in conference action. Villanova has been averaging 77.2 points per game while allowing 70.8 points per contest. The Wildcats have shown they can score in bunches. Villanova has been mediocre defensively, sitting with a 107.3 defensive rating.

DePaul Preview

The DePaul Blue Demons currently sit at 16-13 overall and 8-10 in Big East play, riding some late-season momentum with multiple close victories, including an impressive 72-71 road win vs Creighton and a 62-51 victory over Marquette in their last five games. DePaul has been averaging 71.2 points per game while allowing roughly 69.2 points per contest, a profile that shows slightly below-average offensive output but respectable defense compared to many Big East teams. The Blue Demons don’t typically overwhelm opponents scoring-wise, but they’ve been competitive and have tightened up their defense. DePaul ranks 81st in the NCAA with a 104.6 defensive rating heading into Wednesday.

DePaul vs Villanova Prediction

DePaul will be on the hunt for a third straight win on Wednesday, while Villanova looks for a bounce back win. Exact Villanova to come out aggressive and cover the -3.5 spread in this one. Final score prediction, Villanova wins 78-72.

Betting on College Basketball?

• Join Picks and Parlays premium for free and get a free $30 coupon with code FREE30
• Get started and wager on college hoops today with our favorite online sportsbooks
• Claim a CBB betting bonus offer with the best sportsbook promos

Spend $10 Get 200 in Bonus Picks

Show Bonus Code

Claim Bonus

Signup Promo Recommended Onyx Odds Bonus

Can be redeemed Yes

T&Cs apply, 18+

$200 in No Sweat Entries + A Free Pick

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer

Min. Purchase $10

Requirement $200 Betr Bucks maximum per user ($100 from each Qualifying Entry token)

Playthrough 1x Bonus

Can be redeemed Yes

T&Cs apply, 18+

Get 100% on any coins purchase up to $100

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer Thrillzz Bonus

Can be redeemed Yes

T&Cs apply, 18+

Manchester United vs Ipswich Picks, Prediction, Odds, and Line Movement for Sunday August 30 2026

Manchester United look to bounce back at Old Trafford when they host Ipswich Town, and this preview breaks down the odds, line movement and betting...

Washington Mystics vs Los Angeles Sparks Picks, Prediction, Odds, and Line Movement for Friday August 28 2026

Washington's five-wins-in-six-games surge continues Friday night as the Mystics visit the Los Angeles Sparks, and this preview breaks down the odds, line movement and betting...

Toronto Tempo vs Las Vegas Aces Picks, Prediction, Odds, and Line Movement for Friday August 28 2026

Las Vegas hosts a severely depleted Toronto Tempo roster Friday night in a matchup that heavily favors the home team, and this preview breaks down...

Connecticut Sun vs Indiana Fever Picks, Prediction, Odds, and Line Movement for Friday August 28 2026

Indiana's dominant season series lead sets the stage Friday night at Gainbridge Fieldhouse as the Fever host the Connecticut Sun, and this preview breaks down...

Portland Fire vs Atlanta Dream Picks, Prediction, Odds, and Line Movement for Friday August 28 2026

Atlanta's four-game winning streak gets tested on Friday night as the Dream host the Portland Fire in a matchup between teams heading in opposite directions...

September Fed Hold Chances at 65% on Polymarket Live Odds

The Federal Reserve is still favored to leave interest rates unchanged in September, even after hotter-than-expected inflation data briefly increased expectations for another rate hike....

Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions

Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview