Virginia vs Northwestern Picks and Predictions for Friday, November 21, 2025

By: David Anicetti Published 11/21/2025, 12:45 AM ET

Virginia meets Northwestern in the Greenbrier Tip-Off Mountain Division on Friday, with both teams at 4–0. The Cavaliers are coming off a 104–78 win over Marshall, while the Wildcats edged DePaul 81–79 for their fourth straight victory. Both teams have opened the season with strong defense and solid scoring. Play your ticket and cash in with college basketball picks.

Game Information for Virginia vs Northwestern

Date & Time: Friday, November 21, 5:00 PM ET
Where: Colonial Hall, White Sulphur Springs, WV
TV: CBSSN

Virginia Cavaliers Outlook

Virginia is averaging 90.8 points per game on 50% shooting while grabbing 46.0 rebounds and handing out 19.0 assists. Thijs De Ridder leads the Cavaliers with averages of 17.3 points and 6.0 rebounds while shooting 54.2%. Malik Thomas adds 12.0 points per game, and Chance Mallory has averaged 10.3 points, 3.0 assists, and strong perimeter shooting.

Defensively, the Cavaliers are giving up 61.5 points per game while making 8.3 steals and 7.3 blocks. Center Johann Grunloh has anchored the paint with 7.5 rebounds and 4.3 blocks per game, while Ugonna Onyenso averages 2.5 blocks. Virginia’s combination of rim protection and perimeter defense has allowed it to control opponents. Wins over Marshall, Hampton, North Carolina Central, and Rider have come by wide margins thanks to pressure defense and a solid offense. The best sportsbooks are the best way to go when you are betting on Virginia.

Northwestern Wildcats Outlook

Northwestern is averaging 84.3 points per game while shooting 52.2% from the field. Nick Martinelli leads the team with an average of 20.5 points per game on 62.2% shooting, and Arrinten Page adds 16.0 points and 8.3 rebounds while making 66.7% of his shots. Guard Jayden Reid contributes 12.0 points and 5.8 assists, giving the Wildcats a backcourt playmaker. Northwestern also shares the ball well, matching Virginia with 19.0 assists per game.

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The Wildcats are allowing 60.3 points per game and making 7.5 steals with 4.5 blocks. Page has been a key defender with strong rebounding and shot contesting, while Max Green, Justin Mullins, and Reid have played defense well on the perimeter. Northwestern has handled its schedule comfortably, with home wins over Cleveland State, Boston University, and Mercer before its road win at DePaul. Make sure you know about how the fans are looking on prediction markets for Northwestern with the Onyx Odds promo code.

Virginia vs Northwestern Prediction

Both teams have strong scoring and defense, but Virginia’s interior strength and rim protection give the Cavaliers the advantage on a neutral floor. Northwestern’s scoring will keep this competitive, but Virginia’s ball movement and defensive presence inside will make the difference on Friday. Final Score Prediction: Virginia Cavaliers win and cover ATS, 81–73. Getting the most out of your bets on Virginia vs Northwesstern can be done by using the Fanatics Sportsbook promo code.

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