Arizona vs Colorado Picks & Predictions for Saturday, November 1, 2025

By: Thomas Pemberton Updated 10/31/2025, 08:21 PM ET

The Arizona Wildcats head to Colorado this weekend to take on the Buffalos. Arizona is a -4.5 road favorite and the over/under is set at 53.5 points. Kickoff is scheduled for 7:00 PM est at Folsom Field. Colorado beat Arizona 34-7 in their last meeting last season. Don’t guess on Saturday—grab the smartest plays with our free college football predictions.

Arizona Wildcats Preview

The Arizona Wildcats are 4-3 on the season. Arizona has covered the spread in four games and they carry a 0-2 road record. The Wildcats head into Colorado riding a two game losing streak. Arizona lost to Houston last week 31-28. QB Noah Fifita threw for 269 yards and 2 touchdowns in the win. Fifita has 17 touchdowns with 4 interceptions on the season. Arizona is averaging 31.6 points scored per game. The Wildcats have allowed 31 or more points in back to back games.

Colorado Buffaloes Preview

The Colorado Buffaloes are 3-5 on the season. Colorado has covered the spread in three games this season and they carry a 2-2 home field record. The Buffaloes lost their last game 53-7 against Utah. QB Kaidon Salter threw for just 37 yards with an interception. Salter has 9 touchdowns and 4 interceptions on the season. Salter also leads the Buffaloes with 5 rushing touchdowns. Colorado is averaging 24.9 points scored per game.

Arizona vs Colorado Picks & Predictions

Both Arizona and Colorado are hungry to get back into the win column. Colorado plays better at home. While the Wildcats are winless on the road and in jeopardy of losing three straight games. Colorado shows value as a home underdog. Take those points.

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Final Score Prediction: Arizona Wildcats win 24-21 but the Colorado Buffaloes cover ATS.