Boston College vs Louisville Picks & Predictions for Saturday, October 25, 2025

By: Thomas Pemberton Updated 10/24/2025, 11:59 PM ET

The Louisville Cardinals will host the Boston College Eagles on Saturday. Kickoff is set for 7:30 PM est at L&N Federal Credit Union Stadium. The Cardinals are a -24 point home favorite and the over/under is set at 55 points. Louisville beat Boston College 31-27 in their last meeting last season. Stay ahead of the oddsmakers with insider-level college football predictions.

Boston College Eagles Preview

The Boston College Eagles are 1-6 on the season. Boston College is riding a six game losing streak and they carry a 0-3 road record. The Eagles 2-5 against the spread. Boston College lost to UConn 38-23 in their last game played at home. QB Grayson James threw for 204 yards with 2 touchdowns. RB Turbo Richard leads the Eagles on the ground. Richard has 431 yards and 5 touchdowns with 8 carries. Boston College is averaging 27.1 points per game.

Louisville Cardinals Preview

The Louisville Cardinals are 5-1 on the season. The Cardinals are 3-1 on their home field and are 2-4 ATS. Louisville knocked off #2 ranked Miami 24-21 in their last game on the road. QB Miller Moss threw for 248 yards with 2 touchdowns in the win. Moss has 9 passing touchdowns, 4 rushing touchdowns, and 4 interceptions on the season. Louisville is averaging 34 points scored per game.

Boston College vs Louisville Picks & Predictions

The Louisville Cardinals are 0-4 against the spread at home this season. Louisville is the better team and are at home but they are laying too many points. Watch for a possible let down game by the Cardinals after their huge win last week. Take all those free points. Final Score Prediction: Louisville Cardinals win 34-24 but the Boston College Eagles cover ATS.

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