California vs Louisville Picks and Prediction for Saturday November 8 2025

By: Eddie Kline Updated 11/08/2025, 01:43 AM ET

California Preview

L&N Federal Credit Union Stadium will be rocking on Saturday night, when the California Golden Bears square off against the Louisville Cardinals. Looking to cash in this weekend? Start with our trusted college football picks. The Golden Bears (5-4) rank in the middle of the ACC Conference in total defense and are giving up 25.1 points per game. On Saturday, California turned the ball over twice during a 31-21 home loss versus 15th ranked Virginia.

California senior WR Trond Grizzell hauled in eight receptions for a game-high 80 yards. Kendrick Raphael rushed for 46 yards on 13 carries and found the end zone twice. Aaron Hampton had 15 tackles (7 solo) in a losing effort for the Golden Bears, who were outgained by a substantial 456-263 margin.

Louisville Preview

The Louisville Cardinals have won four of their first five ACC Conference games and still have a chance to reach the conference championship game. The 16th ranked Cardinals (7-1) lead the conference in total defense and are allowing 20.8 points per contest. On Saturday, Louisville erased a nine-point halftime deficit to earn a 28-16 road victory against Virginia Tech.

Louisville turned things around in the third quarter on a 24-yard touchdown pass from Miller Moss to Caullin Lacy and a Keyjuan Brown two-yard touchdown run. Isaac Brown contributed a game-high 130 rushing yards and a score for the Cardinals. Talented WR Chris Bell added eight receptions for 56 yards.

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California vs Louisville Pick

California has already picked up a road victory at Boston College in conference play and was extremely competitive during an overtime loss at Virginia Tech. Louisville tends to do well in the underdog role, but struggles to cover big numbers for head coach Jeff Brohm. Take the Golden Bears plus the points. Final Score Prediction, Louisville Cardinals win 31-20.