Clemson at Louisville Picks and Predictions for Friday, November 14, 2025

By: David Anicetti Published 11/09/2025, 10:39 PM ET

The Clemson Tigers (4–5, 3–4 ACC) visit the No. 15 Louisville Cardinals (7–2, 4–2 ACC) in a key Atlantic Coast Conference matchup. Clemson is 7th in the ACC standings, while Louisville is 3rd. The Tigers defeated Florida State 24–10 last week, and the Cardinals fell 29–26 in overtime to Cal. Score the winning touchdown with our college football picks.

Game Information for Clemson vs Louisville

Kickoff: 7:30 PM ET, November 14

Where: L&N Federal Credit Union Stadium, Louisville, KY

TV: ESPN

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Clemson Game Outlook

Quarterback Cade Klubnik has passed for 1,915 yards with 13 touchdowns and five interceptions, completing 67.2% of his attempts. Bryant Wesco Jr. leads the receivers with 537 yards and six touchdowns, and Antonio Williams has added 367 yards with four scores. Running back Adam Randall has rushed for 522 yards and six touchdowns on 101 carries. Clemson’s offense has topped 28 points in three of its last five games, led by consistent production through the air and a strong running game from Randall.

Linebacker Sammy Brown leads the defense with 58 tackles, while Will Heldt has four sacks. Safety Ricardo Jones has three interceptions, and the Tigers have held opponents under 20 points in three of their last four wins. Kicker Nolan Hauser has been reliable, making 8 of 10 field goals with a long of 50 yards and converting all 29 extra points.

Louisville Game Outlook

Quarterback Miller Moss has thrown for 1,929 yards with 11 touchdowns and six interceptions, completing 65.3% of his passes. Chris Bell leads the team with 743 receiving yards and six touchdowns, and Caullin Lacy has 422 yards and two scores. Running back Isaac Brown has rushed for 782 yards and five touchdowns on 91 carries, averaging 8.6 yards per attempt. Louisville has scored at least 24 points in four of its last five games, combining passing with a steady ground attack.

Linebacker TJ Quinn leads the defense with 59 tackles, and Wesley Bailey has four sacks. Linebacker Antonio Watts has three interceptions, and the defense has forced nine turnovers over the last five games. Kicker Cooper Ranvier is 11-for-13 on field goals with a long of 50 yards and perfect on extra points.

Clemson at Louisville Prediction

Louisville’s passing game with Moss and Bell, along with Brown’s production on the ground, gives the Cardinals more scoring options. Clemson’s defense will compete early, but Louisville’s consistency through the passing attack and red-zone efficiency will decide the outcome. Final Score Prediction: Louisville Cardinals win and cover ATS, 28–20.