Clemson vs North Carolina Picks and Predictions for Saturday, October 4, 2025

By: David Anicetti Published 09/28/2025, 09:12 PM ET

The Clemson Tigers visit the North Carolina Tar Heels on Saturday at Kenan Stadium at 1:00 PM ET on ESPN. Clemson lost 34–21 to Syracuse in its most recent outing and is 1–3 overall, 0–2 in the ACC, sitting near the bottom of the standings. North Carolina fell 34–9 at UCF last Saturday and is 2–2 overall, 0–0 in the ACC, beginning conference play this week. Make a winning interception with our college football predictions.

Clemson Preview

Clemson is led by quarterback Cade Klubnik, who has thrown for 996 yards with six touchdowns and four interceptions. His top option has been Bryant Wesco Jr., who has 24 receptions for 389 yards and five touchdowns. Wesco’s ability to stretch the field gives Clemson big plays, while Adam Randall provides balance for the offense with 338 rushing yards and three scores on the ground.

The Tigers’ defense is strong up front. Will Heldt has three sacks, and linebacker Wade Woodaz leads the team with 35 tackles. Clemson has struggled in close games against Georgia Tech and Syracuse, but the front seven is capable of shutting down its opponents. Limiting turnovers and finding steady drives are key for Clemson to get back on track.

North Carolina Preview

North Carolina will start league play behind quarterback Gio Lopez, who has 430 passing yards with three touchdowns and three interceptions. Jordan Shipp leads the receiving corps with 193 yards and two touchdowns on 13 catches, while Chris Culliver has added a deep threat, evidenced by a 51-yard reception.

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The Tar Heels have running back Demon June, who has rushed for 250 yards at 7.6 yards per carry with one touchdown. June brings speed on the ground to the offense. On defense, linebacker Andrew Simpson leads with 28 tackles, and lineman Melkart Abou Jaoude has two sacks. The unit has shown pressure up front, but will be tested against Clemson’s size in the trenches.

Clemson Tigers vs North Carolina Tar Heels Prediction

Clemson has more proven weapons on offense with Klubnik throwing to Wesco and Randall carrying the ball. North Carolina can keep it close if June can establish a running game early, but Clemson’s defensive front and secondary should be the difference. Final Score Prediction: Clemson wins and covers ATS 31–14.