Colgate vs Syracuse Picks and Predictions for Friday, September 12, 2025

By: David Anicetti Published 09/07/2025, 10:47 PM ET

The Colgate Raiders visit JMA Wireless Dome in Syracuse, New York, on Friday to play the Syracuse Orange at 5:00 PM ET on ACC Network. Syracuse returns home at 1-1 after an overtime win over UConn and a season-opening loss to Tennessee, while Colgate is 0–2 with setbacks to Monmouth and Villanova. Keep up to date with all the College Football action, with our College Football predictions.

Colgate Preview

Colgate’s attack starts with quarterback Zach Osborne, who has 466 passing yards and four touchdowns. Osborne is also the leading rusher with 80 yards. Colgate has scored two rushing touchdowns, and the Raiders have scored five passing touchdowns. Treyvhon Saunders is the explosive piece on the outside, with 360 receiving yards and three scores.

The Colgate defense is led by linebacker Trooper Price with 20 tackles, followed by linebacker Christian Magliacano with 15. Colgate has not made any quarterback sacks but the secondary has performed well before interceptions through the first two games of the regular season.

Syracuse Preview

Syracuse’s offense is led by Steve Angeli, who has 691 passing yards with three touchdowns and two picks. The ground game has been solid, led by Yasin Willis, who has 139 yards and four rushing touchdowns. Dan Villari is the leading receiver with 159 yards. Syracuse has scored four rushing touchdowns and three passing touchdowns.

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The Syracuse defense is led by defensive back Duce Chestnut with 15 tackles, Wild linebacker Gary Bryant III is second with 13. Syracuse has made one quarterback sack but the Orange have not yet intercepted any passes. Lineman Kevin Jobity Jr has the only quarterback sack for Syracuse

Colgate vs Syracuse Prediction

Syracuse is much more talented on both sides of the line of scrimmage and will be a tough opponent for FCS Colgate. The Orange have too much offense for the Raiders to stop on a regular basis, and on defense, Syracuse will produce plenty of three-and-outs and prevent Colgate from mounting any sustained drives. Final Score Prediction: Syracuse Orange win and cover ATS 39-3.