Colorado vs Houston Picks and Predictions for Friday, September 12, 2025

By: David Anicetti Published 09/07/2025, 10:48 PM ET

The Colorado Buffaloes visit TDECU Stadium in Houston, Texas, on Friday to play the Houston Cougars at 7:30 PM ET on ESPN. Colorado is 1–1 after falling to Georgia Tech 27-20 and beating Delaware 31-7. Houston is 2–0 with a 27-0 win at home and a 35-9 victory on the road against Rice. Keep up to date with all the College Football action, with our College Football predictions.

Colorado Preview

Colorado has a dynamic quarterback in Kaidon Salter, who has 261 passing yards with one touchdown pass. Simeon Price leads the ground game with 85 rushing yards, and Sincere Brown has the team lead through the air with 120 receiving yards and a touchdown. Colorado has shown much less firepower on offense this season after losing several skill position players to the NFL and the transfer portal.

Colorado's defense is led by linebacker Reginald Hughes with 14 tackles, and safety Carter Stoutmire is second with 12. Colorado has made three quarterback sacks, and the Buffaloes have made two interceptions. Colorado's defense will be key if the Buffaloes hope to contend for a conference title, as the offense is not quite as strong as it was last season

Houston Preview

Houston’s offense is led by quarterbackConner Weigman, who has 347 passing yards with four touchdowns. Dean Connors gives them a steady running game with 182 rushing yards and two touchdowns, and tight end Tanner Koziol leads the passing game with 115 yards and a touchdown. The Cougars are balanced on attack and can beat opponents on the ground or through the air, which will be necessary against a tough Colorado defense.

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Houston's defense is led by linebacker Jalen Garner and defensive back Latrell McCutchin Sr with 13 tackles apiece. Wrook Brown and Kentrell Webb each have 11 tackles. Houston has made five quarterback sacks through the first two games of the regular season and the Cougars have intercepted three passes.

Colorado vs Houston Prediction

Houston’s strong running game and passing attack, paired with a defense that’s already displayed how well it can rush the passer and defend against the run, are examples of why the Cougars are favored and the choice in this matchup with Colorado. Final Score Prediction: Houston Cougars win and cover ATS 28-17.