Duke vs North Carolina Picks & Prediction for Saturday, November 22, 2025

By: Thomas Pemberton Updated 11/22/2025, 01:28 AM ET

The Duke Blue Devils head to Chapel Hill to take on the North Carolina Tar Heels. Kickoff is scheduled for 3:30 PM est at the ACC Network. Duke is a -6.5 road favorite and the over/under is set at 51.5 points. Duke beat UNC last season 21-20. Get the edge this weekend with our free college football picks backed by data and trends.

Duke Blue Devils Preview

The Duke Blue Devils are 5-5 on the season. Duke heads to North Carolina with a 3-2 road record. The Blue Devils are riding a two game losing streak. Duke lost to Virginia 34-17 in their last game played. QB Darian Mensah threw for 213 yards with a touchdown. Mensah has 25 touchdowns and 4 interceptions on the season. WR Cooper Barkate leads the Blue Devils with 53 catches for 869 yards and 6 touchdowns. Duke is averaging 33.4 points scored per game. The best sportsbooks are the best way to go when you are betting on Duke.

North Carolina Tar Heels Preview

The North Carolina Tar Heels are 4-6 on the season. The Tar Heels carry a losing 2-3 home field record. North Carolina lost to Wake Forest 28-12 in their last game. QB Gio Lopez threw for 201 yards. Lopez has 8 touchdowns and 5 interceptions on the season. WR Jordan Shipp leads the Tar Heel offense. Shipp has 44 catches and 4 touchdowns. North Carolina is averaging 18.7 points scored per game. Make sure you know about how the fans are looking on prediction markets for North Carolina with the Onyx Odds promo code.

Duke v North Carolina Picks & Prediction

The Duke Blue Devils are 4-6 against the spread. While North Carolina has covered the spread in five games. Duke has been the better team this season but they are in jeopardy of losing a third straight game. Watch for North Carolina to keep this game close. The underdog shows the best value. Getting the most out of your bets on Duke vs North Carolina can be done by using the Fanatics Sportsbook promo code.

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