Duke vs Syracuse Picks and Predictions for Saturday, September 27, 2025

By: David Anicetti Updated 09/27/2025, 01:35 AM ET

The Duke Blue Devils visit the Syracuse Orange at JMA Wireless Dome on Saturday, September 27, 2025, at 12:00 p.m. ET. Duke is 2–2 and won its most recent game 45–33 vs NC State. Syracuse is 3–1 and won its most recent game 34–21 at Clemson. From underdogs to point spreads, we’ve got your back with free college football picks.

Duke Preview

QB Darian Mensah is off to a strong start with 1,305 yards, 11 touchdowns, and 2 interceptions. Mensah’s biggest targets are Cooper Barkate (337 yards), Sahmir Hagans (4 TD), and Andrel Anthony (3 TD). The ground game helps with Anderson Castle (193 yards, 3 TD) and Nate Sheppard (188 yards). Duke has given up 7 sacks, and needs to tighten its pass protection.

On defense, DE Vincent Anthony Jr. has 5 sacks and is tough to stop when one-on-one. S DaShawn Stone leads with 31 tackles. Duke’s keys are to make big stops on first and second downs and not allow third and short. K Todd Pelino is 6-for-9 on field goals and perfect on extra points.

Syracuse Preview

QB Steve Angeli has 1,316 yards, 10 touchdowns, and 2 interceptions. WR Darrell Gill Jr. is the top threat (310 yards receiving, 3 TDs). Justus Ross-Simmons is the red-zone target (5 TDs) for Angeli. RB Yasin Willis leads the ground game with 233 yards and 4 TDs. The line has allowed 11 sacks, and must give Angeli more protection against Duke.

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The defense tackles well. LB Gary Bryant III leads with 21 stops. DBs Duce Chestnut and Braheem Long Jr. challenge throws and have shown the ability to move up and make tackles. Special teams are steady with K Tripp Woody at 5-for-6 on field goals and perfect on extra points.

Duke vs Syracuse Prediction

Both teams can throw. Duke brings more pass rush; Syracuse has the better recent result and home field. Syracuse will finish more drives in the end zone and while Duke will be stopped more often on the road. Final Score Prediction: Syracuse Orange win and cover ATS 31-24.