Georgia Southern vs USC Picks and Prediction September 6 2025

By: Dylan Hellebrand Published 09/01/2025, 09:09 PM ET

Georgia Southern vs USC Game Infor

On Saturday, the Georgia Southern Eagles (0-1) face off against the USC Trojans (1-0) at Los Angeles Memorial Coliseum in Los Angeles, California. The game will air on FS1. Make sure you are ready for all the football action with our college football picks.

USC Preview

USC comes into this matchup having won their season opener last weekend. In their dominant 73-13 victory over Missouri State, USC quarterback Jayden Maiava delivered an efficient performance, completing 15 of his 18 pass attempts for 295 yards and two touchdowns. On the ground, running back King Miller contributed 80 rushing yards, while quarterback Husan Longstreet added another 54 rushing yards, displaying strong mobility. Wide receiver Makai Lemon led the Trojans’ receiving corps with 90 yards through the air. USC has averaged 38 points per game over their last five games. The Trojans aim to continue this high-powered offensive display and secure another convincing home win to maintain their perfect start to the season. Last season, USC averaged 30.2 points per game, and they are eager to build on that mark as they strive to stay undefeated through two weeks. USC is favored by 27.5 points with the over/under set at 63.5 total points.

Georgia Southern Preview

Georgia Southern enters this game on a one-game losing streak. In their 42-14 defeat against Fresno State, Georgia Southern’s quarterback JC French IV completed 17 of his 28 pass attempts, totaling 158 passing yards. He managed to throw two touchdown passes but also had one interception during the game. On the ground, running back OJ Arnold led the team with 41 rushing yards, while fellow running back David Mbadinga contributed an additional 20 yards. The team’s top receiver in the contest was Camden Brown, who hauled in passes for 55 yards. Over their last five games, which includes the end of last season, the Eagles' defense has given up an average of 25.4 points per game. As they prepare to travel to Los Angeles for a challenging matchup against USC, Georgia Southern will be hoping to pull off a significant upset. Offensively, the Eagles averaged 26.8 points per game throughout last season.

USC vs Georgia Southern Trends

Georgia Southern was 4-2 on the road last season
The Eagles averaged 25 points on the road
USC was 4-2 at home last season
The Trojans averaged 36.8 points at home

USC vs Georgia Southern Pick

USC demonstrated impressive offensive strength on their home field last season, and they'll aim to continue that momentum as they host Georgia Southern in Los Angeles. Meanwhile, Georgia Southern enters the matchup with confidence, having secured victories in four of their six road games last year. They will rely heavily on their defensive unit to set the tone early and challenge USC’s high-powered offense right from the opening whistle. Final Score Prediction, USC Trojans win and cover the spread, 44-12.

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