Indiana vs Iowa Picks and Predictions for Saturday, September 27, 2025

By: David Anicetti Updated 09/27/2025, 01:33 AM ET

The Indiana Hoosiers visit Kinnick Stadium to face the Iowa Hawkeyes on Saturday, September 27, 2025, at 3:30 p.m. ET on Peacock. Indiana is 4–0 after a 63–10 win over Illinois. Iowa is 3–1 after a 38–28 win at Rutgers. Get more winners and fewer bad beats with our free college football predictions.

Indiana Preview

Quarterback Fernando Mendoza is off to a sharp start: 975 yards, 14 touchdowns, and no interceptions. His top target is Omar Cooper Jr. (19 catches, 377 yards, 5 TDs), with Elijah Sarratt close behind (24 receptions, 256 yards, 5 TDs). Protection has been solid with only 3 sacks allowed, and the pass game has a 58-yard gain to Cooper Jr.

The run game is strong as well: 1,235 yards on 182 carries (6.8 per rush) with 11 touchdowns. Kaelon Black leads (306 yards, 7.0 per carry), while Roman Hemby (265 yards) and Khobie Martin (222 yards, 4 TDs) add to the depth on the ground. On defense, Isaiah Jones has 3 sacks, Louis Moore has 23 tackles, and Amare Ferrell has 2 interceptions.

Iowa Preview

Iowa’s offense is led by its ground game. The Hawkeyes have 802 rushing yards at 4.7 yards per carry with 10 rushing touchdowns. Quarterback Mark Gronowski has six rushing scores and 492 yards passing with 3 touchdowns and 1 interception. Jaziun Patterson (198 yards, 5.8 per carry) and Xavier Williams (186 yards) handle most of the carries, while Sam Phillips leads the receivers with 115 yards.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

The front seven puts pressure on the passer. Iowa has 10 sacks, led by Max Llewellyn (4) with help from Ethan Hurkett (2). Linebacker Jaden Harrell has 28 tackles. Takeaways have been limited so far (one interception). Kicker Drew Stevens is 7-for-9 on field goals with a long of 55.

Indiana vs Iowa Prediction

Indiana has the better team on both sides of the line of scrimmage. The Hoosiers throw it well, run it well, and protect the ball. Iowa can run, but its passing numbers are just average, and the defense has not taken the ball away often. Indiana will be on the road, but wins in this Big 10 showdown. Final Score Prediction: Indiana Hoosiers win and cover ATS 31-17.