Indiana vs Ohio State Picks and Predictions for Saturday, December 6, 2025

By: Cameron Ross Published 11/30/2025, 11:24 PM ET

Indiana vs Ohio State Information

The Indiana Hoosiers will be in Lucas Oil Stadium Saturday night at 8:00 PM for a Big 10 championship matchup against the Ohio State Buckeyes. Indiana is the #2-ranked team in the nation with twelve wins this season, coming into the Big 10 championship following a 53-point road victory over Purdue. The Ohio State Buckeyes are the number one-ranked team in the nation, undefeated this season, following an 18-point road victory over Michigan to conclude the regular season. Stay in the news with our College Football Picks.

Indiana Preview

Fernando Mendoza leads the Indiana offense this season with 2758 yards and 32 touchdowns on 211 completions to go along with 243 yards and six scores on 64 carries. Roman Hemby leads the way on the ground for Indiana with 866 yards and six touchdowns on 163 carries. Omar Cooper Jr. is the top receiver on the team with 840 yards and 11 touchdowns on 58 receptions. Elijah Sarratt has added 650 yards and 11 touchdowns on 48 catches this season. Make sure you know about how the fans are looking on prediction markets for Indiana with the Thrillz promo code.

Ohio State Preview

Julian Sayin leads the Ohio State offense this season with 3065 yards and 30 touchdowns on 258 completions. Bo Jackson is the top ball carrier on the team with 952 yards and five touchdowns on 151 carries. CJ Donaldson has chipped in 89 carries for 330 yards and 10 scores. Jeremiah Smith is the top target in the Ohio State offense with 942 yards and 11 touchdowns on 72 receptions. Carnell Tate has added 44 catches for 793 yards and eight scores this season. Make the most of your bets on Ohio State by using the sportsbook promos.

Indiana vs Ohio State Prediction

This is a matchup between the top two teams in the nation, and it will live up to the billing on Saturday. Both teams are undefeated this season, and will compete start to finish on Saturday. Look for Indiana to stay close enough throughout the Big 10 championship to cover the number, but Ohio State will get the win when the dust settles over Indiana. Final Score Prediction: Ohio State Buckeyes win, but the Indiana Hoosiers cover 31-27. Make sure when you place your Indiana vs Duke bet you are using the bet365 bonus code.

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