Indiana vs. Oregon Picks and Prediction For Saturday October 11, 2025

By: Dylan Hellebrand Updated 10/10/2025, 10:43 PM ET

On Saturday, the Indiana Hoosiers (5-0) face off against the Oregon Ducks (5-0) at Autzen Stadium in Eugene, Oregon. The game will be aired on CBS. Discover which teams the pros are backing with our daily college football picks.

Game Information For Indiana vs Oregon

October 11, 2025, 3:30pm EST
Autzen Stadium
CBS
54° rainy at start time

Oregon Form & Recent Results

Oregon enters this game riding the momentum of a five-game winning streak, remaining unbeaten to start the season. Two weeks ago, the Ducks pulled out a thrilling 30-24 victory over Penn State in double overtime, a game where quarterback Dante Moore truly shined. Moore completed 29 of his 39 pass attempts and tossed three touchdown passes, showcasing both his accuracy and poise under pressure. So far this year, Moore has already racked up 1,210 passing yards, cementing his role as the leader of Oregon’s high-octane offense. On the ground, Oregon has found a reliable one-two punch with running backs Dierre Hill Jr. and Jayden Limar, who have rushed for 270 and 232 yards, respectively. In the receiving corps, Dakorien Moore has emerged as a top target with 296 receiving yards, helping to keep opposing defenses guessing. The Ducks’ offense has been firing on all cylinders through their first five games, putting up an impressive average of 46.6 points per game. This marks a significant jump from last season, when they averaged 35.7 points per game. Now, with confidence sky-high, Oregon is set to face another major test as they host seventh-ranked Indiana, hoping to secure their second straight win against a top-10 opponent this time in front of their home crowd.

Indiana Form & Recent Results

Indiana comes into this matchup riding high with five straight wins to start the season. In their hard-fought 20-15 victory over Iowa two weeks ago, quarterback Fernando Mendoza put together a solid performance, completing 13 of his 23 passes for two touchdowns and one interception for the Hoosiers. Through those first five games, Mendoza has accumulated an impressive 1,208 passing yards, showing his reliability under center. The running game has also been a big asset for Indiana this year, with Roman Hemby racking up 351 yards on the ground and fellow running back Kaelon Black close behind with 344 rushing yards. Wide receiver Omar Cooper Jr. has emerged as a top target for Mendoza, hauling in 432 yards so far this season. Offensively, Indiana has been nothing short of explosive. Averaging 47.8 points per game in their first five matchups, their high-powered attack has kept defenses on their heels, comparable to the kind of firepower Oregon is known for. This upcoming game in Eugene is shaping up to be one of the biggest tests of the season for the Hoosiers as they hope to make a statement on the road. For context, Indiana averaged 38.3 points per contest last year, which was the second-highest mark in all of college football, highlighting just how dangerous their offense continues to be.

Key Players For Indiana and Oregon

Indiana QB Fernando Mendoza: 89/122, 16 TD, 1 INT
Oregon QB Dante Moore: 100/134, 14 TD, 1 INT

Betting Odds & Market Overview:

ORE -7.5; O/U 54.5

Indiana vs Oregon Picks and Prediction

A marquee showdown is set to unfold in Eugene, where the third-ranked Oregon Ducks are set to host the seventh-ranked Indiana Hoosiers in what promises to be a thrilling battle. Both teams have been nearly unstoppable on offense so far this season, lighting up the scoreboard and making a statement in each of their first five games. With so much talent on both sides, this matchup has all the makings of a classic, and whichever team comes out on top will earn a huge statement win on the national stage. Final Score Prediction, Oregon Ducks win but fail to cover the spread, 30-28.

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