Iowa vs USC Picks and Prediction for Saturday November 15 2025

By: Eddie Kline Updated 11/15/2025, 12:11 AM ET

Iowa Preview

A Top 25 college football showdown will take place on Saturday afternoon, when the Iowa Hawkeyes square off against the USC Trojans from the Los Angeles Memorial Coliseum. Maximize your wagers by reading our free college football picks before kickoff. The 20th-ranked Hawkeyes (6-3) rank third in the Big Ten Conference and are allowing 13.1 points per game. On Saturday, Iowa turned the ball over twice during an 18-16 home loss versus ninth-ranked Oregon.

Iowa trailed 15-7 entering the fourth quarter, but rallied to take the lead on a Drew Stevens 58-yard field goal and a Mark Gronowski three-yard touchdown run. Gronowski also threw a three-yard touchdown pass to D.J. Vonnahme. Kamari Moulton rushed for a team-high 83 yards on 23 carries for the Hawkeyes.

USC Preview

The USC Trojans have won five of their first six Big Ten conference games and need to win their final three games to reach the College Football Playoff. The 19th-ranked Trojans (7-2) rank second in the conference in total offense and are averaging a shade below 40 points per contest. On Friday, USC outgained visiting Northwestern by 202 yards during a convincing 38-17 victory.

USC Jayden Maiava completed 24 of 33 passes for 299 yards and a pair of touchdowns. Junior WR Makai Lemon caught 11 passes for a career-high 161 yards and two scores. King Miller added 127 rushing yards and a touchdown for the Trojans.

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Iowa vs USC Pick

USC has won seven of the ten all-time meetings versus Iowa, but the Hawkeyes won the most recent matchup in 2019. Iowa has the better defense and special teams, which makes them a live underdog on the road. Take the points. Final Score Prediction, USC Trojans win 24-23.