Kentucky vs South Carolina Picks and Prediction for Saturday September 27 2025

By: Eddie Kline Updated 09/27/2025, 01:25 AM ET

Kentucky Preview

SEC Conference foes will square off on Saturday night, when the Kentucky Wildcats battle the South Carolina Gamecocks from Williams-Brice Stadium. Saturday success begins with free college football picks you can rely on. The Wildcats (2-1) are looking to rebound from a disappointing four-win season and are scoring 31.7 points per game. Last time out, Kentucky scored at least ten points in each quarter on their way to a 48-23 home victory versus Eastern Michigan.

Kentucky raced out to a 14-0 first quarter lead on a pair of touchdowns from RB Seth McGowan (104 rush yds). Senior TE Josh Kattus hauled in three passes for 61 yards and a score. The Wildcats rushed for 252 yards on 46 carried and converted 5 of 11 third down attempts.

South Carolina Preview

The South Carolina Gamecocks finished the 2024 campaign as one of the hottest teams in college football, but have dropped their first two SEC Conference games this season. The Gamecocks (2-2) rank last in the conference in total offense and are averaging just 22.3 points per contest. On Saturday, South Carolina allowed Missouri to score the final 11 points during a 29-20 road loss.

South Carolina built a 14-12 halftime advantage and stayed ahead entering the fourth quarter on two William Joyce field goals. LaNorris Sellers completed 18 of 28 passes for 302 yards and two scores. The Gamecocks were limited to negative nine rushing yards on 22 attempts.

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Kentucky vs South Carolina Pick

Kentucky got thumped by visiting South Carolina last year by a 31-6 final score. The Gamecocks have lost plenty of talent from last season’s squad and the Wildcats are coming off a bye. Take Kentucky to get revenge and pull off the upset on the road. Final Score Prediction, Kentucky Wildcats win 24-23.