Louisville vs SMU Picks & Prediction for Saturday, November 22, 2025

By: Thomas Pemberton Updated 11/22/2025, 01:28 AM ET

Week 13 of college football features a lot of good games. The SMU Mustangs will host the Louisville Cardinals on Saturday. Kickoff is scheduled for noon est at Gerald J. Ford Stadium. SMU is a -3.5 favorite and the over/under is set at 53.5 points. SMU beat Louisville 34-27 last season in their last meeting. Get the edge this weekend with our free college football picks backed by data and trends.

Louisville Cardinals Preview

The Louisville Cardinals are 7-3 on the season. The Cardinals head into this weekend riding a two game losing streak. Louisville has played good football on the road and carry a 3-0 away record. The Cardinals lost their last game 20-10 against Clemson. Louisville was shutout in the 4th quarter of the loss. RB Keyjuan Brown was the top player on offense. Brown rushed for 135 yards on 15 carries. QB Miller Moss has 11 touchdowns and 7 interceptions on the season. Moss hasn't thrown a touchdown in two straight games. The Louisville Cardinals are averaging 399 yards of offense per game with 31.5 points scored per game. The best sportsbooks are the best way to go when you are betting on Louisville.

SMU Mustangs Preview

The SMU Mustangs are also 7-3 on the season. SMU is riding a two game win streak and carry a 4-1 home field record. The Mustangs beat Boston College 45-13 in their last game. QB Kevin Jennings threw for 326 yards with 3 touchdowns and 1 interception. Jennings has 21 touchdowns and 9 interceptions on the season. The SMU Mustangs are averaging 406 yards per game with 32.2 points scored. RB TJ Harden has been the Mustangs standout offensive player. Harden has 133 carries, 612 rushing yards, and 6 rushing touchdowns. Make sure you know about how the fans are looking on prediction markets for SMU with the Onyx Odds promo code.

Louisville vs SMU Picks & Prediction

The Louisville Cardinals are 3-6 against the spread on the season. While the SMU Mustangs have covered the spread in four games. Louisville has played solid on the road and SMU has been great on their home field. These two teams are very evenly matched but SMU has all the momentum. Watch for the Mustangs to find a way to win their third straight game. Louisville offense won't be able to keep up such a fast pace. Lay the points with SMU at home. Getting the most out of your bets on Louisville vs SMU can be done by using the Fanatics Sportsbook promo code.

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