Louisville vs. Virginia Tech Picks and Prediction for Saturday, November 1, 2025

By: Jake Allman Updated 10/31/2025, 08:23 PM ET

Louisville heads to Blacksburg for a key ACC matchup with Virginia Tech at Lane Stadium on Saturday. The 19th-ranked Cardinals enter at 6-1 overall and 3-1 in conference play, while the Hokies sit at 3-5 and 2-2 in the ACC. Kickoff is set for 3:00 PM ET on The CW Network, with temperatures expected in the low 50s. Louisville rides a two-game winning streak after a 38-24 victory over Boston College, while Virginia Tech looks to build on a thrilling 42-34 double-overtime win against Cal. Don’t guess on Saturday—grab the smartest plays with our free college football predictions.

Louisville Preview

Louisville’s offense continues to perform well behind quarterback Miller Moss, who has thrown for 1,793 yards with 10 touchdowns and five interceptions while completing nearly 65 percent of his passes. Running back Isaac Brown has powered the ground attack with 652 yards and four scores on 75 carries, averaging over eight yards per touch. The passing game leans heavily on Chris Bell, who leads the team with 687 yards and six touchdowns. Louisville’s attack has been effective in finishing drives and maintaining possession. Linebacker TJ Quinn anchors the defense with 49 tackles, while lineman Wesley Bailey has recorded four sacks to pressure opposing quarterbacks.

Virginia Tech Preview

Virginia Tech’s offense has relied on dual-threat quarterback Kyron Drones, who has accounted for 1,516 passing yards and 14 touchdowns to just six interceptions. His ability to extend plays has been vital for a unit that has shown big play potential but remains inconsistent. Running back Marcellous Hawkins has added 531 yards on the ground, providing a strong interior running option, while Ayden Greene offers a reliable target in the passing game with 365 yards and two touchdowns. The Hokies’ defense, led by Kaleb Spencer’s 42 tackles and Kemari Copeland’s four sacks, has struggled against highly talented offenses but has shown improvement at home.

Virginia Tech vs Louisville Pick

The matchup favors Louisville’s effective offense and quarterback play. The Cardinals’ ability to control the clock and capitalize on red-zone trips gives them a distinct edge. Virginia Tech will need to generate turnovers and win on early downs to stay competitive, but Louisville’s balanced attack and experience make that a tall task. Expect the Cardinals to dictate pace and pull away late behind Moss and a strong rushing attack.

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Prediction: Louisville 31, Virginia Tech 14