Michigan State vs Indiana Picks and Prediction for Saturday October 18 2025

By: Eddie Kline Updated 10/17/2025, 09:15 PM ET

Michigan State Preview

Memorial Stadium will play host to a Saturday afternoon Big Ten Conference clash between the Michigan State Spartans and the Indiana Hoosiers. Make sure you are ready for all the football action with our college football picks. The Spartans (3-3) are one of five teams without a victory in conference play and are surrendering 31.8 points per game. On Saturday, Michigan State trailed by 17 points at halftime and failed to convert all four fourth down attempts during a 38-13 home loss versus UCLA.

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Michigan State QB Aidan Chiles started the scoring with a two-yard touchdown run and was forced to leave the game with an apparent head injury. Nick Marsh caught seven passes for a game-high 77 yards and a score for the Spartans.

Indiana Preview

The Indiana Hoosiers have taken the college football world by storm and are sitting atop the conference standings with Ohio State. The third-ranked Hoosiers (6-0) lead the Big Ten in total defense and are allowing a stingy 11.3 points per contest. Last week, Indiana racked up 23 first downs and force a pair of turnovers during a 30-20 road victory against Oregon.

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QB Fernando Mendoza entered the Heisman Trophy conversation and put Indiana ahead to stay with an eight-yard touchdown pass to Elijah Sarratt. Roman Hemby contributed a game-high 70 rushing yards and scored twice for the Hoosiers. Aiden Fisher registered 13 tackles and Kellan Wyatt added 1.5 sacks.

Michigan State vs Indiana Pick

Michigan State QB Aidan Chiles (head) was unable to return during Saturday’s loss and his status for this game is uncertain. The Spartans have only gone winless in Big Ten Conference play once and could be in danger of doing so this year. The Hoosiers crushed the Spartans in East Lansing 47-10 in 2024 and can name the score here. Take Indiana to cover. Final Score Prediction, Indiana Hoosiers win 44-10.