Michigan State vs Iowa Picks and Prediction for Saturday, November 22, 2025

By: Jake Allman Updated 11/22/2025, 01:32 AM ET

Michigan State heads into Iowa City trying to break out of a seven-game Big Ten losing streak while Iowa looks to secure bowl positioning and rebound from back-to-back close losses. Iowa sits at 6–4 and 4–3 in conference play, and the matchup predictor leans heavily toward the Hawkeyes. Michigan State comes in at 3–7 with a stretch of tough defeats, including losses to Penn State, Minnesota, and Michigan. Looking for today’s college football picks? Don’t miss our expert breakdowns.

Michigan State Preview

Michigan State’s offense has relied on Aidan Chiles, who has thrown for 1,392 yards with 10 touchdowns and only 3 interceptions. He completes over 63 percent of his passes and gives the Spartans a chance to create explosive plays when protected. Makhi Frazier leads the rushing attack with 520 yards, and Nick Marsh is the top receiving threat with 559 yards and 5 touchdowns. The pieces are there for Michigan State to move the ball, but consistency has been a major issue. The Spartans have struggled to sustain drives, and recent results show an offense that stalls too easily, especially against disciplined defenses.

Michigan State’s defensive unit has had trouble flipping momentum, producing some tackles for loss but not enough takeaways. Jordan Hall leads the team with 74 tackles, and Jalen Thompson has 2.5 sacks, yet the group hasn’t generated enough game-changing plays. The Spartans’ recent stretch shows opponents controlling the line of scrimmage and finishing drives in key spots. That trend becomes especially concerning when heading into Kinnick Stadium. Check out all the sportsbook promos to see if you are getting a great deal on your bets on Michigan State.

Iowa Preview

Iowa enters with a strong team despite the recent setbacks. The Hawkeyes beat Penn State, Wisconsin, and Minnesota during a midseason surge and remained competitive in close losses to Oregon and USC. Mark Gronowski has thrown for 1,216 yards with 6 touchdowns while providing mobility and toughness. The run game remains Iowa’s backbone, led by Kamari Moulton with 612 yards at 5.1 per carry. Iowa’s offense isn’t explosive, but it is steady and capable of wearing down opponents.

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The Iowa defense holds the biggest edge in this matchup. The Hawkeyes swarm the ball, generate pressure, and rarely give up explosive plays. They have multiple players with interceptions, Max Llewellyn has produced 6 sacks, and the front seven consistently controls early downs. That’s a major challenge for a Michigan State team that hasn’t executed well on third down and hasn’t protected long enough to let Chiles fully settle into games. Make sure you know about how the fans are looking on prediction markets for Iowa with the Kickr promo code.

Iowa vs Michigan State Prediction

Prediction: Iowa 27, Michigan State 13. Iowa spread. The matchup favors Iowa on both sides, and Michigan State’s struggles in conference play point toward another comfortable Hawkeye win. Make sure when you place your bet on Michigan State vs Iowa you are using the BetMGM bonus code.