Mississippi State vs Florida Picks and Prediction for Saturday October 18 2025

By: Eddie Kline Updated 10/17/2025, 09:18 PM ET

Mississippi State Preview

In Saturday afternoon college football action, the Mississippi State Bulldogs will travel to Ben Hill Griffin Stadium to take in the Florida Gators. Make sure you are ready for all the football action with our college football picks. The Bulldogs (4-2) have already doubled last year’s win total and are averaging 33.7 points per game for second year head coach Jeff Lebby. Last time out, Mississippi State managed just 219 yards and turned the ball over twice during a 31-9 road loss against sixth-ranked Texas A&M.

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Mississippi State finally found the end zone midway through the fourth quarter on a 44-yard strike from Blake Shapen to Brenen Thompson. S Jahron Manning registered a game-high 13 tackles (6 solo) for the Bulldogs, who surrendered 479 yards to the Aggies.

Florida Preview

The Florida Gators are playing one of the most difficult schedules in the country and will be hard pressed to become bowl eligible. The Gators (2-4) have been impressive on the defensive side of the ball and are giving up 19.8 points per contest. On Saturday, Florida was limited to a field goal over the final three quarters and committed a pair of turnovers during a 34-17 road loss against fifth-ranked Texas A&M.

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Florida jumped out to an early 7-0 lead on a one-yard touchdown pass from D.J. Lagway to Amir Jackson. Lagway added a six-yard touchdown to talented freshman WR Dallas Brown and finished with 245 passing yards. Vernell Brown III caught six passes for 77 yards in a losing effort for the Gators.

Mississippi State vs Florida Pick

Florida holds a substantial edge in the all-time series and defeated Mississippi State in Starkville last season by a 45-28 final score. The Bulldogs are coming off a bye and are allowing just 19.8 points per game. Take an improved Mississippi State team to cover on the road. Final Score Prediction, Florida Gators win 28-24.