Mississippi State vs. Missouri Picks and Prediction, November 15, 2025

By: Dylan Hellebrand Updated 11/15/2025, 12:15 AM ET

On Saturday, the Mississippi State Bulldogs (5-5) face off against the Missouri Tigers (6-3) at Memorial Stadium in Columbia, Missouri. This game will be aired on the SEC Network. Looking for today’s college football picks? Don’t miss our expert breakdowns.

Game Information for Mississippi State vs Missouri

November 15, 2025
7:45pm EST
Memorial Stadium
SEC Network
62° at start time

Missouri Form & Recent Results

Missouri enters this game hoping to turn things around after losing their last two matchups, and three of their last five overall. In their most recent game, Missouri fell to Texas A&M by a score of 38-17. Quarterback Matt Zollers had a tough time, completing just 7 out of 22 passes. Over the course of the season, Zollers has thrown for 1,685 yards. The Tigers’ ground game has been led by Ahmad Hardy, who has rushed for 1,046 yards. In the passing attack, Kevin Coleman Jr. has been Zollers’ favorite target, picking up 559 yards, while Marquis Johnson has contributed 340 yards of his own. Defensively, Missouri has struggled a bit lately, giving up an average of 21 points in their past five games. With their recent difficulties, the Tigers are eager to regroup in front of their home crowd and break their losing skid against Mississippi State.

Mississippi State Form & Recent Results

Mississippi State heads into this matchup trying to bounce back after dropping four of their last five games. Most recently, they suffered a 41-21 defeat against Georgia. In that game, quarterback Kamario Taylor completed 6 out of 10 passes for the Bulldogs. On the season, quarterback Blake Shapen has thrown for 2,234 yards through the air, providing a steady presence for the offense. In the backfield, Fluff Bothwell leads the ground attack with 534 rushing yards this year, closely followed by Davon Booth, who has 513 rushing yards to his name. At receiver, Brenen Thompson has been the top target, racking up 808 yards so far. Defensively, Mississippi State has struggled recently, giving up an average of 35 points over their last five games. The Bulldogs are hoping to tighten things up on defense and avoid picking up their sixth conference loss of the year.

Key Players

MSST QB Kamario Taylor: 176/270, 15 TD, 6 INT
MIZ QB Beau Pribula: 158/227, 11 TD, 7 INT

Betting Odds & Market Overview:

MIZ -6.5; O/U 51.5

Mississippi State vs Missouri Picks and Prediction

Missouri is aiming to break their current two-game losing skid and pick up a third SEC win this season, hoping to get back on track and avoid slipping further down the standings with another defeat, this time against Mississippi State. On the other side, the Bulldogs are coming in determined to secure a win that would make them officially eligible for a bowl game, adding extra motivation as both teams fight for momentum late in the season. Final Score Prediction, Missouri Tigers and cover the spread, win 35-17.

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