NC State vs Pittsburgh Panthers Picks & Predictions for Saturday, October 25, 2025

By: Thomas Pemberton Updated 10/25/2025, 12:00 AM ET

The North Carolina State Wolfpack remain on the road as they head to Pittsburgh to take on the Panthers. Pittsburgh is a -8.5 home favorite and the total is set for 58.5 points. The Wolfpack beat the Panthers 30-29 in their last meeting back in 2020. Kickoff is scheduled for 3:30 PM est at Acrisure Stadium. Stay ahead of the oddsmakers with insider-level college football predictions.

North Carolina State Wolfpack Preview

The NC State Wolfpack are 4-3 on the season. North Carolina State is 1-2 on the road this season. The Wolfpack are 3-4 against the spread. NC State lost to Notre Dame in their last game 36-7. QB CJ Bailey threw for 186 yards with a touchdown and 3 interceptions. Bailey has 14 passing touchdowns with 7 interceptions on the season. RB Hollywood Smothers leads NC State in the rushing attack. Smothers has 739 yards on 112 carries and 5 touchdowns.

Pittsburgh Panthers Preview

The Pittsburgh Panthers are 5-2 on the season. The Panthers have won three straight games and carry a 3-1 home field record. Pittsburgh has covered the spread in five games this season. The Panthers are averaging 38.4 points scored per game. Pittsburgh beat Syracuse in their last game played 30-13. QB Mason Heintschel threw for 143 yards with an interception. Heintschel has 6 passing touchdowns, 1 rushing touchdown, and 3 interceptions on the season.

North Carolina State vs Pittsburgh Picks & Predictions

The Pittsburgh Panthers are seeking a fourth straight win. Pittsburgh is 3-1 against the spread at home this season. North Carolina State carries a losing road record and are coming off of a loss. Watch for the Panthers to be the better team on both sides of the ball on their home field. Final Score Prediction: Pittsburgh Panthers win 31-21 and cover ATS.

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