Ohio State vs Washington Picks and Predictions for Saturday, September 27, 2025

By: David Anicetti Updated 09/27/2025, 01:34 AM ET

The Ohio State Buckeyes visit Husky Stadium to face the Washington Huskies on Saturday, September 27, 2025, at 3:30 p.m. ET on CBS. Ohio State is 3–0 after a 37–9 win over Ohio. Washington is 3–0 after a 59–24 win at Washington State. From underdogs to point spreads, we’ve got your back with free college football picks.

Ohio State Preview

Quarterback Julian Sayin has been strong passing for 779 yards, 8 touchdowns, and 3 interceptions, with an 87-yard TD pass. Jeremiah Smith leads all receivers with 315 yards and three TD receptions, while Carnell Tate has 219 yards and three TD catches. Tight ends Will Kacmarek and Jelani Thurman give Ohio State over the middle targets. The Buckeyes have allowed just 1.0 sacks.

The run game is balanced. Bo Jackson has 217 yards on 18 carries (long 64) with 1 score, and CJ Donaldson has 151 yards and 2 touchdowns. On defense, Caden Curry has 2 sacks, and linebacker Arvell Reese leads with 20 tackles. Playmakers in the secondary - Caleb Downs and Jermaine Mathews Jr. - have already had an interception. Kicker Jayden Fielding is 3-for-3 on field goals.

Washington Preview

Quarterback Demond Williams Jr. has delivered well with 778 yards, 6 touchdowns, no interceptions, with a long pass of 59 yards. Washington uses speed on the outside with Denzel Boston, who has 249 yards and three touchdowns. Receivers Dezmen Roebuck and Jonah Coleman have also contributed to the passing attack.

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The ground game is the bread and butter for the Huskies. Jonah Coleman has 347 yards and 9 touchdowns on 51 carries, while Washington has a team 780 rushing yards, averaging 6.0 per carry, and 15 rushing scores. On defense, Washington brings pressure with 8 sacks led by Isaiah Ward and Jacob Lane (both at 1.5). Safety Alex McLaughlin has 2 interceptions, and linebacker Deven Bryant has 17 tackles. Grady Gross is 2-for-2 on field goals with a long of 51 yards.

Ohio State vs Washington Prediction

This matchup will be back and forth with plenty of action. Washington runs the ball well and hits deep passes, but Ohio State protects better and has more ways to score. With Sayin throwing to Smith and Tate, plus a steady dose of Bo Jackson, the advantage goes to Ohio State on the road. Final Score Prediction: Ohio State Buckeyes win and cover ATS 35-21