Ohio vs Buffalo Picks and Predictions for Friday, November 28, 2025

By: David Anicetti Published 11/24/2025, 12:09 AM ET

Ohio (7–4, 5–2 MAC) visits Buffalo (5–6, 4–3 MAC) in the final regular-season game for both programs. The Bobcats enter after a 42–14 win over UMass, while the Bulls look to rebound from a 37–20 loss to Miami (OH). With bowl positioning and conference standing at stake, each side has plenty of incentive to win. Build your edge with our college football picks.

Ohio vs Buffalo Game Information

Kickoff: 12:00 PM ET
Date: November 28
Where: UB Stadium, Buffalo, NY
TV: ESPNU

Ohio Bobcats Preview

Parker Navarro leads the Ohio offense with 2,085 passing yards, 12 touchdowns, and nine interceptions while completing 63.0% of his passes. Sieh Bangura powers the running game with 1,123 yards and 13 touchdowns. Chase Hendricks serves as the primary receiver with 858 yards and six scores. Across the last five games, the Bobcats have averaged 31.0 points scored.

Defensively, safety Jalen Thomeson leads Ohio with 73 tackles. Jay Crable adds five sacks, and the unit has generated 18 total sacks. Michael Mack II leads the secondary with two interceptions, contributing to 10 team picks. Ohio has allowed an average of 18.6 points over its last five games, and the defense has limited big gains through strong pursuit and disciplined man-to-man coverage. Make sure you know about how the fans are looking on prediction markets for Ohio with the Fliff promo code.

Buffalo Bulls Preview

Quarterback Ta’Quan Roberson has produced 2,250 passing yards, 15 touchdowns, and 11 interceptions while completing 57.8% of his attempts. Al-Jay Henderson anchors the ground game with 724 yards and five touchdowns, and Nik McMillan leads the receivers with 859 yards and three scores. As an offense, Buffalo averages about 225 passing yards and 135 rushing yards per game. Across the last five games, the Bulls have averaged 22.2 points scored.

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On defense, Red Murdock leads with 128 tackles. Junior Poyser’s 5.5 sacks highlight a front responsible for 36 team sacks, and Jalen McNair leads with two interceptions. Buffalo has allowed an average of 24.6 points per game in its last five outings. The best sportsbooks are the best way to go when you are betting on Buffalo.

Ohio vs Buffalo Prediction

Ohio enters with stronger recent scoring, a productive rushing game behind Bangura, and a defense that has held opponents below 20 points per game in its last five matchups. Buffalo has capable players, but the Bobcats’ running game and solid defense create clear advantages for Ohio. Final Score Prediction: Ohio Bobcats win and cover ATS, 24–13. Make sure when you place your Ohio vs Buffalo bet you are using the bet365 bonus code.