Oklahoma State vs Oregon Picks and Prediction for Saturday September 6 2025

By: Cameron Ross Published 09/02/2025, 11:34 PM ET

Oklahoma State Preview

The Oklahoma State Cowboys will be on the road for the first time this week with a game in Oregon against the Oregon Ducks. Oklahoma State is undefeated this season following a 20-point victory to open the new year. Offensively, Oklahoma State was the better team a week ago, scoring 27 points on 359 total yards of offense. Defensively, Oklahoma State controlled the game, giving up just seven points on 225 yards and forcing one turnover. Stay in the action with our College Football Picks.

Zane Flores led the Oklahoma State offense a week ago, completing 13 passes for 136 yards. Hauss Hejny completed 5 passes for 96 yards and one score and ran the ball four times for 27 yards and one touchdown in the game. Kalib Hicks led all ball carriers in the game for Oklahoma State with 56 yards on 21 carries. Sesi Vailahi added 32 yards and one score on 9 carries. Terrill Davis led the team with 75 yards on 2 grabs.

Oregon Preview

The Oregon Ducks are the number 7-ranked team in the nation coming into Week 2 undefeated after a 46-point blowout victory in game one of the year. The Oregon defense controlled the game in week 1, giving up only 13 points on 244 yards after allowing only three third-down conversions. Offensively, Oregon dominated, scoring 59 points over 35 in the first half on 506 total yards.

Dante Moore led the way for the Oregon offense a week ago, completing 18 passes for 213 yards and three touchdowns. Noah Whittington was the top ball carrier on the roster with 68 yards and one touchdown on 10 carries. Jordan Davis chipped in 26 yards and three scores on 6 carries in the game period. Malik Benson led all receivers for Oregon with 51 yards and one score on five catches, while Gary Bryant Jr. chipped in four catches for 31 yards and one touchdown.

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Oklahoma State vs Oregon Pick

Both teams come into this week undefeated, but Oregon is ranked inside the top ten. Look for the Ducks, who dominate this game on both sides of the ball, as Oklahoma State had some issues against a lackluster team a week ago. Take Oregon this week to control this game on both sides of the ball, leading to the blowout win and cover at home. Final Score Prediction, Oregon Ducks win and cover 49-7.