Ole Miss vs Oklahoma Picks and Prediction for Saturday, October 25, 2025

By: Cameron Ross Updated 10/24/2025, 11:53 PM ET

Ole Miss vs Oklahoma Information

The Ole Miss Rebels will be on the road this week with the game inside Memorial Stadium against the Oklahoma Sooners. Ole Miss is the #8-ranked team in the nation with six wins and one loss on the year, following their first loss of the season last week against Georgia. The Oklahoma Sooners will be back at home this week with six wins and one loss overall, having won four of the last five, currently ranked #13 in the nation. Win or lose comes down to preparation—see today’s college football predictions from the experts.

Ole Miss Preview

Trinidad Chambliss leads the Ole Miss offense this season with 1549 yards and eight touchdowns on 104 completions to go along with 325 yards and five touchdowns on 70 carries. Austin Simmons has completed 34 passes for 580 yards and four scores this season. Kewan Lacy leads the team out of the backfield with 618 yards and 10 touchdowns on 138 carries. Harrison Wallace III is the top target on the roster with 400 yards and two touchdowns on 21 catches.

Oklahoma Preview

John Mateer leads the Oklahoma offense this season with 1567 yards and seven scores on 133 completions and has added 65 carries for 209 yards and five scores. Tory Blaylock is the top ball carrier on the Oklahoma roster with 87 carries for 391 yards and four touchdowns. Isaiah Sategna III leads the way for Oklahoma with 37 catches for 493 yards and four scores this season.

Ole Miss vs Oklahoma Prediction

Both teams are playing good football coming into this game, as each has just one loss. Oklahoma will have the edge in this matchup as they will be at home. Take Oklahoma to do the work this week as they get the win and cover at home to hand Ole Miss their second consecutive loss. Final Score Prediction, Oklahoma Sooners win and cover 27-21

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