Penn State at Ohio State Picks and Predictions for Saturday, November 1, 2025

By: David Anicetti Updated 10/31/2025, 08:26 PM ET

The Penn State Nittany Lions visit the Ohio State Buckeyes on Saturday in a Big Ten showdown. Penn State is 3–4 overall and 0–4 in conference play, while Ohio State is 7–0 and 4–0 in the Big Ten. Penn State has dropped four straight since a 52–6 win over Villanova, and Ohio State has won every game by multiple scores during October. Confident betting starts with the right insights—check out our college football predictions now.

Game Information for Ohio State vs Penn State

Kickoff: Saturday, November 1, 12:00 p.m. ET

Location: Ohio Stadium, Columbus, Ohio

TV: FOX

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Penn State Preview

Quarterback Drew Allar has completed 103 of 159 passes (64.8%) for 1,100 yards with 8 touchdowns and 3 interceptions. The ground game is led by Kaytron Allen, who has 612 yards on 98 carries with 9 scores; Nicholas Singleton has chipped in with 274 yards and 6 touchdowns. Penn State has reached 24+ points in three of its last four but has struggled late in one-score losses to Iowa (25–24) and Northwestern (22–21).

On defense, linebacker Amare Campbell leads with 51 tackles, while Zane Durant has contributed with interior pressure and an interception. The Nittany Lions have 14 sacks this season and five interceptions, but recent opponents have finished drives in the fourth quarter, which has handed Penn State more losses. A lack of success in the red zone late has caused the Nittany Lions to lose games late, during their current skid.

Ohio State Preview

Quarterback Julian Sayin has been solid under center for the Buckeyes, going 156 of 195 (80.0%) for 1,872 yards with 19 touchdowns and 3 interceptions. Freshman star Jeremiah Smith leads the receivers (49 receptions, 602 yards, 7 TDs), and Bo Jackson paces the running game (68 carries, 644 yards, 6.4 yards per carry). The Buckeyes posted a 34–0 win at Wisconsin, 34–16 at Illinois, and a 42–3 win over Minnesota, with solid passing mixed in with a strong running attack..

Defensively, Caden Curry headlines the pass rush with 7 sacks and 34 total tackles, while Arvell Reese has 42 tackles and 5.5 sacks. The secondary features playmakers like Caleb Downs and Davison Igbinosun, and Ohio State has held five straight opponents to 16 points or fewer. The front seven has produced 21 sacks and consistent tackles for losses that force long-yardage situations.

Penn State at Ohio State Prediction

Penn State needs to protect the ball, not commit turnovers, and production from Allen to keep drives moving. Ohio State has the stronger form and an excellent passing game, and will limit big gains from Penn State, putting the Nittany Lions into third-down and long situations. The visitors stay close, but only for a short while, as Ohio State will pull away in the second half with big plays on offense and a suffocating defense. Final Score Prediction: Ohio State Buckeyes win and cover ATS 40-10.