Purdue vs. Notre Dame Picks and Prediction, September 20, 2025

By: Dylan Hellebrand Published 09/14/2025, 10:35 PM ET

On Saturday, the Purdue Boilermakers (2-1) face off against the Notre Dame Fighting Irish (0-2) at Notre Dame Stadium in Notre Dame, Indiana. The game will be aired on NBC and Peacock. Keep up to date with all the College Football action, with our College Football predictions.

Game Information For Purdue vs Notre Dame

September 20, 2025, 3:30pm EST, Notre Dame Stadium, NBC/Peacock
73° cloudy at start time

Notre Dame Form & Recent Results

Notre Dame enters this game hoping to turn things around after dropping their first two matchups of the season. Last week, the Fighting Irish fell just short in a high-scoring 41-40 contest against Texas A&M. In that game, quarterback CJ Carr completed 20 of his 32 passing attempts, throwing for one touchdown but also recording an interception. Over the first two games, Carr has accumulated 514 passing yards as he settles into his role under center. On the ground, running back Jeremiyah Love leads the backfield with 127 rushing yards, closely followed by fellow running back Jadarian Price, who has contributed 113 yards. In the passing game, tight end Eli Randon has emerged as a reliable target, collecting a team-high 182 receiving yards so far this season. Defensively, the Fighting Irish have struggled, giving up an average of 34 points per game through their first two games. With these defensive challenges and an 0-2 record to start the year, Notre Dame will be eager to secure their first victory and recapture the form that saw them average 36.1 points per game last season.

Purdue Form & Recent Results

Purdue heads into this matchup looking to bounce back after a 33-17 defeat at the hands of USC, which ended their brief winning streak. In that game, quarterback Ryan Browne completed 24 out of 39 passes, throwing for one touchdown but also giving up three interceptions. Browne has accumulated 786 passing yards so far this season, leading the Boilermakers’ offense. On the ground, running back Devin Mockobee has been the primary rusher, picking up 230 yards, while Browne himself has contributed 59 yards rushing. Wide receiver Arhmad Branch has emerged as one of Browne’s top targets, posting 167 receiving yards to date. During their first three games this season, the Boilermakers have averaged 27.3 points per game. As Purdue prepares to face a struggling, winless Notre Dame squad on the road, they’ll be aiming for a much-needed victory to keep their season on track. For comparison, last season the Boilermakers managed just 12.7 points per game, so their offensive output has improved significantly this year.

Key Players For Notre Dame and Purdue

Purdue QB Ryan Browne: 56-for-88, 5 TD, 4 INT
Notre Dame QB CJ Carr: 39-for-62, 3 TD, 2 INT

Betting Odds & Market Overview for Purdue vs Notre Dame:

ND -26.5; O/U 52.5

Picks and Prediction Notre Dame vs Purdue

Notre Dame’s season couldn’t have started any worse as they look to avoid starting the season with three consecutive losses. They'll try to regroup and turn things around as they prepare to host Purdue at home. Purdue, on the other hand, has had a stronger start, picking up victories in two of their first three contests. Now, with momentum on their side, the Boilermakers are aiming to notch a statement win by upsetting Notre Dame in front of their home crowd. Final Score Prediction, Notre Dame Fighting Irish win, but fail to cover the spread, 38-15.

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