SE Louisiana vs LSU Picks and Prediction, September 20, 2025

By: Thomas Pemberton Published 09/14/2025, 10:04 PM ET

The LSU Tigers get set to host the SE Louisiana Lions this Saturday. The Tigers last played the Lions back in 2018 when they won 31-0. LSU looks to stay unbeaten through four weeks. While SE Louisiana hopes to win their biggest game of the season. Be sure to check out all of our expert's free college football picks.

LSU Tigers Preview

The LSU Tigers are a perfect 3-0 on the season. The Tigers have already beaten Clemson and Florida on the season. LSU has scored a total of 60 points this season while allowing 27 points against. The Tigers are averaging 20 points scored per game this season with a total of 345 yards per game. QB Garrett Nussmeier has 3 passing touchdowns on the season with 2 interceptions. Aaron Anderson has been Nussmeier's top target. Anderson has 247 receiving yards on 18 catches. Running back Caden Durham has 45 carries on the season with 196 yards and 2 touchdowns.

SE Louisiana Lions Preview

The SE Louisiana Lions have bounced back nicely after their season opening loss. The Lions have won two straight games which include a 56-3 blowout over Mississippi Valley State last week. SE Louisiana played two QB's in last week's win who combined for 5 touchdown passes and no interceptions. The Lions are averaging 17.7 points on the season with 177 rushing yards per game. SE Louisiana is 2-1 against the spread heading into LSU.

SE Louisiana vs LSU Picks & Prediction

The LSU Tigers are the clear and better team. LSU just needs to get through this game with no injuries with a big game coming up against Ole Miss next week. SE Louisiana will leave it all on the field but will be outmatched and outplayed in just about every play. LSU gets it done but we may see some second stringers early. Take all the points with the Lions.

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Final Score Prediction: LSU Tigers win 34-14 but the SE Louisiana Lions cover ATS.