SMU vs. Clemson Picks and Prediction for Saturday October 18, 2025

By: Dylan Hellebrand Updated 10/17/2025, 09:19 PM ET

On Saturday, the SMU Mustangs (4-2) face off against the Clemson Tigers (3-3) at Memorial Stadium in Clemson, South Carolina. The game will be aired on ACC Network. Keep up to date with all the College Football action, with our College Football predictions.

Get a taste of the pros! With 7 days of Flex Picks FREE, you’ll receive daily access to a different expert handicapper — no commitment, no hidden fees. Use FREE7 at checkout and start your free trial today. [GET STARTED]

Game Information for SMU vs Clemson

October 18, 2025
3:30pm EST
Memorial Stadium
ACC Network
78° sunny at start time

Clemson Form & Recent Results

Clemson enters this game riding the momentum of a two-game winning streak, having come out on top in three of their last five. Last week, the Tigers dominated Boston College with a convincing 41-10 victory. Quarterback Cade Klubnik led the way, completing 22 of his 30 pass attempts for 1 touchdown and 1 interception. So far this season, Klubnik has accumulated 1,530 passing yards, helping to drive Clemson’s offense. On the ground, running back Adam Randall has contributed 404 rushing yards over the course of the season. In the receiving corps, Bryant Wesco Jr. leads the team with 537 receiving yards, while fellow wideout T.J. Moore has added 283 yards. Offensively, Clemson has been averaging nearly 30 points per game in their last five games, showing signs of improvement after suffering a few early-season defeats. Overall this season, the Tigers are putting up an average of 26.3 points per game as they aim to continue building momentum.

SMU Form & Recent Results

SMU comes into this matchup riding the momentum of a two-game winning streak and boasting victories in three of their last five games. In their recent 34-10 triumph over Stanford, quarterback Kevin Jennings turned in an impressive performance by completing 22 of his 30 pass attempts and tossing two touchdowns to help lead the Mustangs to victory. Jennings has been a key contributor all season, having racked up 1,658 passing yards so far. On the ground, running back T.J. Harden has emerged as SMU’s leading rusher with 415 yards, while fellow back Chris Johnson Jr. has chipped in with 226 yards of his own. The Mustangs have also benefited from a strong receiving corps, with wide receiver Romello Brinson collecting 484 receiving yards this season. Offensively, SMU has been firing on all cylinders lately, putting up an average of 32.4 points over their last five games. Overall, they’re averaging 34 points per game, a stat they’ll look to replicate as they head into a challenging road game against Clemson, hoping to keep their winning streak alive and make another statement.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Key Players for SMU and Clemson

SMU QB Kevin Jennings: 137/191, 15 TD, 6 INT
Clemson QB Cade Klubnik: 133/202, 11 TD, 5 INT

Betting Odds & Market Overview:

CLEM -9.5; O/U 54.5

Clemson vs SMU Picks and Prediction

Clemson has had a tough season so far, but they're hoping to turn things around when they take on conference rival SMU at home. The Tigers will be eager to give their fans something to cheer about at Memorial Stadium and notch a much-needed victory. On the other side, SMU comes into this matchup having won four of their first six games and will be aiming to claim their fifth win of the season. The Mustangs would love nothing more than to silence the Clemson faithful with an impressive road win. Final Score Prediction, Clemson Tigers win and cover the spread, 36-21.