SMU vs TCU Picks and Predictions for Saturday, September 20, 2025

By: David Anicetti Published 09/14/2025, 09:06 PM ET

SMU meets TCU on Saturday at Amon G. Carter Stadium in Fort Worth. Kickoff is set for 12:00 p.m. ET on ESPN2. The Mustangs come in at 2–1 after beating Missouri State 28–10, while the Horned Frogs are 2–0 after a 42–21 win over Abilene Christian. Kick a big field goal with our expert football picks

SMU Preview

Quarterback Kevin Jennings has been sharp, completing 70.5%of his throws for 836 yards and six touchdowns, but has been picked off three times. Romello Brinson caught 15 passes for 314 yards and three scores to lead all receivers. T.J. Harden leads on the ground with 253 yards and five rushing touchdowns. Protecting Jennings is key, as he has already been sacked six times.

On defense, safety Isaiah Nwokobia leads the team with 21 tackles. Ahmaad Moses has a sack and a 95-yard pick-six, while Cameron Robertson has also added a sack. This defense has forced some timely turnovers but will be tested by TCU’s run game and play-action.

TCU Preview

Quarterback Josh Hoover has spread the ball around well, throwing for 621 yards with six touchdowns on 48 completions. His top target has been Jordan Dwyer, who has 225 yards and two touchdowns. TCU’s rushing attack has been explosive, with Kevorian Barnes averaging 7.4 yards per carry on 21 carries, including a 75-yard touchdown run. As a team, the Frogs are averaging 6.1 yards per carry.

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Defensively, safety Jamel Johnson leads with 14 tackles, while Bud Clark has one interception. TCU has six sacks so far, with edge pressure from Zach Chapman and Jonathan Bax. The Frogs’ speed gives them an edge against SMU’s offensive line.

SMU vs TCU Prediction

SMU has the firepower to stay in it, but TCU’s balance on offense and home-field advantage will be too much for the Mustangs to keep pace. Expect the Frogs to control the second half and finish ahead at least a touchdown. TCU wins a close one. Final Score Prediction: TCU Horned Frogs win and cover ATS 39-27