SMU vs Wake Forest Picks & Predictions for Saturday, October 25, 2025

By: Thomas Pemberton Updated 10/24/2025, 11:59 PM ET

The SMU Mustangs travel to Wake Forest on Saturday to take on the Demon Deacons. Both teams will be putting their current win streaks on the line. SMU is a -3.5 road favorite and the over/under is set for 53.5 points. Stay ahead of the oddsmakers with insider-level college football predictions.

SMU Mustangs Preview

The SMU Mustangs are 5-2 on the season. SMU is riding a three game win streak and they carry a 2-1 road record. The Mustangs are 2-5 against the spread this season. SMU beat Clemson 35-24 in their last game on the road. QB Kevin Jennings threw for 290 yards with 2 touchdowns and 1 interception. Jennings has 15 passing touchdowns with 6 interceptions on the season. TJ Harden leads the rushing attack. Harden has 414 yards on 85 carries with 5 touchdowns. SMU is averaging 34.1 points scored per game with 408 total yards of offense.

Wake Forest Demon Deacons Preview

The Wake Forest Demon Deacons are 4-2 on the season. The Demon Deacons are riding a two game win streak and they carry a 2-2 home field record. Wake Forest beat Oregon State 39-14 in their last game played on the road. QB Deshawn Purdie threw for 270 yards with 4 touchdowns. Purdie has 5 touchdowns on the year. Wake Forest is averaging 29 points scored per game. RB Demond Claiborne leads the ground attack. Claiborne has 539 rushing yards on 69 carries with 8 touchdowns.

SMU vs Wake Forest Picks & Predictions

Both SMU and Wake Forest have been playing good football as of late. SMU is seeking their fourth straight win. While Wake Forest is seeking their third straight win. Wake Forest show value as a home underdog. Watch for a tight offensive battle in this matchup. Final Score Prediction: SMU Mustangs win 28-27 but the Wake Forest Demon Deacons cover ATS.

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